Evidence map›Paper›PMID 31882536›Full record

ArticleThe Journal of biological chemistry2020

Transmembrane helix 6b links proton and metal release pathways and drives conformational change in an Nramp-family transition metal transporter.

Aaron T Bozzi, Anne L McCabe, Benjamin C Barnett, Rachelle Gaudet

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Determinants of metal import and specificity in a bacterial transporter.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. International journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Nramp: Deprive and conquer?Frontiers in cell and developmental biology · 2022
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aaron T BozziDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Anne L McCabeDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Benjamin C BarnettDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 gaudet@mcb.harvard.edu.ORCID 0000-0002-9177-054X
Harvard University · US

Funding

Mechanism of Divalent Metal Transport by NRamp-Family TransportersR01GM120996 · NIGMS · HARVARD UNIVERSITY · PI GAUDET, RACHELLE · 2017 to 2024
$3.0M
NIGMS NIH HHS R01 GM120996
6 · The paper itself

Abstract

The natural resistance-associated macrophage protein (Nramp) family encompasses transition metal and proton cotransporters that are present in many organisms from bacteria to humans. Recent structures of

Indexed as

Amino Acid SequenceCation Transport ProteinsCobaltDeinococcusHistidineHydrophobic and Hydrophilic InteractionsIon TransportManganeseMetalsModels, MolecularMutationNatural Resistance-associated Macrophage Protein 1Protein ConformationProtein Processing, Post-TranslationalProtonsCation Transport ProteinsCobaltHistidineManganeseMetalsNatural Resistance-associated Macrophage Protein 1Protonsconformational changeconformational cyclecysteine accessibilitydivalent metal transporter 1 (DMT1)manganesemembrane transportmetal homeostasisMntHnatural resistance-associated macrophage protein (Nramp)proton transporttransportertransport metal

Identifiers

PMID31882536
PMCPMC6996879
OpenAlexW2998466113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.