Evidence map›Paper›PMID 31882528›Full record

ArticleNeurology2020

Unique white matter structural connectivity in early-stage drug-naive Parkinson disease.

Virendra R Mishra, Karthik R Sreenivasan, Zhengshi Yang, Xiaowei Zhuang, Dietmar Cordes, Zoltan Mari, Irene Litvan, Hubert H Fernandez, David Eidelberg, Aaron Ritter and 2 more

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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Virendra R MishraFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ. mishrav@ccf.org ryan.walsh@barrowneuro.org.ORCID 0000-0002-0452-6400
Karthik R SreenivasanFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Zhengshi YangFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Xiaowei ZhuangFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Dietmar CordesFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Zoltan MariFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Irene LitvanFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Hubert H FernandezFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
David EidelbergFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Aaron RitterFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Jeffrey L CummingsFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ.
Ryan R WalshFrom Imaging Research (V.R.M., K.R.S., Z.Y., X.Z., D.C.), Lou Ruvo Center for Brain Health (Z.M., A.R., J.L.C.), Cleveland Clinic Foundation, Las Vegas, NV; Departments of Psychology and Neuroscience (D.C.), University of Colorado at Boulder; Department of Neurosciences (I.L.), University of California San Diego, La Jolla; Center for Neurological Restoration (H.H.F.), Cleveland Clinic, OH; Center for Neurosciences (D.E.), Feinstein Institute for Medical Research, Manhasset, NY; UNLV Department of Brain Health (J.L.C.), School of Integrated Health Sciences, Las Vegas, NV; and Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ. mishrav@ccf.org ryan.walsh@barrowneuro.org.

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

objectiveTo investigate the topographic arrangement and strength of whole-brain white matter (WM) structural connectivity in patients with early-stage drug-naive Parkinson disease (PD).

methodsWe employed a model-free data-driven approach for computing whole-brain WM topologic arrangement and connectivity strength between brain regions by utilizing diffusion MRI of 70 participants with early-stage drug-naive PD and 41 healthy controls. Subsequently, we generated a novel group-specific WM anatomical network by minimizing variance in anatomical connectivity of each group. Global WM connectivity strength and network measures were computed on this group-specific WM anatomical network and were compared between the groups. We tested correlations of these network measures with clinical measures in PD to assess their pathophysiologic relevance.

resultsPD-relevant cortical and subcortical regions were identified in the novel PD-specific WM anatomical network. Impaired modular organization accompanied by a correlation of network measures with multiple clinical variables in early PD were revealed. Furthermore, disease duration was negatively correlated with global connectivity strength of the PD-specific WM anatomical network.

conclusionBy minimizing variance in anatomical connectivity, this study found the presence of a novel WM structural connectome in early PD that correlated with clinical symptoms, despite the lack of a priori analytic assumptions. This included the novel finding of increased structural connectivity between known PD-relevant brain regions. The current study provides a framework for further investigation of WM structural changes underlying the clinical and pathologic heterogeneity of PD.

Indexed as

AgedDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedNerve NetParkinson DiseaseWhite Matter

Identifiers

PMID31882528
PMCPMC7136053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.