Evidence map›Paper›PMID 31882503›Full record

ArticleIn vivo (Athens, Greece)

Combined Atezolizumab and Chemotherapy for a Patient With Double Primary Cancers.

Shinichiro Okauchi, Yuika Sasatani, Gen Ohara, Katsunori Kagohashi, Hiroaki Satoh

Open access · diamondAbstract readCase Reports
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Simultaneous Head and Neck and Lung Cancers: Implications and Therapeutic Management Timing.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026
    Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shinichiro OkauchiDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.
Yuika SasataniDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.
Gen OharaDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.
Katsunori KagohashiDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.
Hiroaki SatohDivision of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan hirosato0809@yahoo.co.jp.
University of Tsukuba · JPNational Hospital Organization Mito Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune checkpoint inhibitors are indicated for non-small cell lung cancer (NSCLC) and head and neck cancer, and combined treatment of immune checkpoint inhibitor and chemotherapy has recently been carried out in patients with NSCLC. However, there is no established standard therapy for synchronous locally advanced or metastatic cancers of lung and nasopharynx. CASE REPORT: We report a case of a metastatic lung adenocarcinoma and locally advanced epipharyngeal carcinoma successfully treated with chemotherapy and immune checkpoint inhibitor, paclitaxel, carboplatin, bevacizumab and atezolizumab. The tumor proportion score of programmed death ligand 1 was 5-10% and 70-80% for metastatic lung adenocarcinoma and locally advanced epipharyngeal carcinoma, respectively. Shrinkage of both carcinomas was confirmed, and the treatment effect was judged to be a partial response.

conclusionThis was the first patient who was treated with this combination treatment. Our clinical experience suggests that this treatment could be one of the options for patients with these advanced cancers and an overall good clinical condition.

Indexed as

Adenocarcinoma of LungAgedAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsB7-H1 AntigenBevacizumabBone NeoplasmsCarboplatinHumansLung NeoplasmsMalePaclitaxelPharyngeal NeoplasmsPrognosisAntibodies, Monoclonal, HumanizedatezolizumabB7-H1 AntigenBevacizumabCarboplatinCD274 protein, humanPaclitaxelAtezolizumabchemotherapyepipharyngeal carcinomalung adenocarcinoma

Identifiers

PMID31882503
PMCPMC6984065
OpenAlexW2997871848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.