Evidence map›Paper›PMID 31882484›Full record

ArticleIn vivo (Athens, Greece)

Low-grade Fibromyxoid Sarcoma: Treatment Outcomes and Efficacy of Chemotherapy.

Florence Chamberlain, Bodil Engelmann, Omar Al-Muderis, Christina Messiou, Khin Thway, Aisha Miah, Shane Zaidi, Anastasia Constantinidou, Charlotte Benson, Spyridon Gennatas and 1 more

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  17. Superficial low-grade fibromyxoid sarcoma.Journal of cutaneous pathology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Florence ChamberlainSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Bodil EngelmannSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Omar Al-MuderisSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Christina MessiouSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Khin ThwaySarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Aisha MiahSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Shane ZaidiSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Anastasia ConstantinidouBank of Cyprus Oncology Center, Strovolos, Cyprus.
Charlotte BensonSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Spyridon GennatasSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K.
Robin L JonesSarcoma Unit, The Royal Marsden NHS Foundation Trust, London, U.K. robin.jones4@nhs.net.
Bank of Cyprus Oncology Center · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype with a generally indolent pattern of clinical behaviour, but treatments for advanced disease are limited. PATIENTS AND

methodsA retrospective search of a prospectively maintained institutional database identified 102 patients treated from December 1994 to August 2018. We evaluated the outcome of patients and the efficacy and safety of non-surgical therapies in LGFMS.

resultsNinety-four out of 102 (92.2%) underwent primary resection, seven (6.9%) were treated with systemic therapy and one (1.0%) is currently being treated with pre-operative radiotherapy. The RECIST 1.1 response rate to first-line chemotherapy was 0%, and median progression-free survival was 1.84 months (95% confidence intervaI=0.10-3.6 months).

conclusionConventional systemic therapy has limited efficacy in advanced LGFMS.

Indexed as

AdultAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleFibromaFibrosarcomaFollow-Up StudiesHumansMaleMiddle AgedNeoplasm GradingProspective StudiesRetrospective StudiesSurvival Ratechemotherapychromosomal translocationLGFMSLow-grade fibromyxoid sarcomaradiotherapy

Identifiers

PMID31882484
PMCPMC6984074
OpenAlexW2998053810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.