Evidence map›Paper›PMID 31882463›Full record

ArticleIn vivo (Athens, Greece)

Hypermethylation of Corticotropin Releasing Hormone Receptor-2 Gene in Ulcerative Colitis Associated Colorectal Cancer.

Masayoshi Kobayashi, Nagahide Matsubara, Yutaka Nakachi, Yasushi Okazaki, Motoi Uchino, Hiroki Ikeuchi, Jihyng Song, Kei Kimura, Michiko Yasuhara, Akihito Babaya and 6 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Masayoshi KobayashiDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Nagahide MatsubaraDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan nagamb@hyo-med.ac.jp.
Yutaka NakachiDivision of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan.
Yasushi OkazakiDivision of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Japan.
Motoi UchinoDepartment of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Hiroki IkeuchiDepartment of Inflammatory Bowel Disease, Division of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Jihyng SongDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Kei KimuraDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Michiko YasuharaDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Akihito BabayaDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Tomoki YamanoDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Masataka IkedaDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Hiroki NishikawaCenter for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan.
Ikuo MatsudaDepartment of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Seiichi HirotaDepartment of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Naohiro TomitaDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Hyogo Medical University · JPSaitama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe difficulty of early diagnosis of colitis associated colorectal cancer (CACRC) due to colonic mucosal changes in long-standing ulcerative colitis (UC) patients is often experienced in daily clinical practice. Noninvasive objective monitoring for cancer development is advantageous for optimizing treatment strategies in UC patients. We aimed to examine the epigenetic alterations occurring in CACRC, focusing on DNA hypermethylation of CpG islands. MATERIALS AND

methodsThe level of DNA methylation in CpG cites was compared between CACRC and the counterpart non-tumorous mucosa using Infinium HumanMethylation 450K BeadChip.

resultsOur subjects included 3 males and 3 females (median age, 49.5 years). The 450K CpG site DNA methylation microarray revealed that the difference in β value (level of hypermethylation) was the highest for corcicotropin releasing hormone receptor 2 (CRHR2) between CACRC and counterpart non-tumorous mucosa.

conclusionDetection of hypermethylation of CRHR2 may be promising for cancer screening in UC patients.

Indexed as

AdultColitis, UlcerativeColonColorectal NeoplasmsCpG IslandsDNA MethylationFemaleHumansIntestinal MucosaMaleMiddle AgedReceptors, Corticotropin-Releasing HormoneCRF receptor type 2Receptors, Corticotropin-Releasing Hormonecarcinogenesiscolitis associated colorectal cancercorticotropin releasing hormone receptor 2epigenetic alterationhypermethylationUlcerative colitis

Identifiers

PMID31882463
PMCPMC6984071
OpenAlexW2997715569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.