Evidence map›Paper›PMID 31882451›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Direct visualization of degradation microcompartments at the ER membrane.

Sahradha Albert, Wojciech Wietrzynski, Chia-Wei Lee, Miroslava Schaffer, Florian Beck, Jan M Schuller, Patrice A Salomé, Jürgen M Plitzko, Wolfgang Baumeister, Benjamin D Engel

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 105 citations in OpenAlex.

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  8. Proteasome dynamics in response to metabolic changes.Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sahradha AlbertDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Wojciech WietrzynskiDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Chia-Wei LeeDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Miroslava SchafferDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Florian BeckDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Jan M SchullerDepartment of Structural Cell Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Patrice A SaloméDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0003-4452-9064
Jürgen M PlitzkoDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.ORCID 0000-0002-6402-8315
Wolfgang BaumeisterDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; baumeist@biochem.mpg.de engelben@biochem.mpg.de.
Benjamin D EngelDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany; baumeist@biochem.mpg.de engelben@biochem.mpg.de.ORCID 0000-0002-0941-4387
Max Planck Institute of Biochemistry · DEUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To promote the biochemical reactions of life, cells can compartmentalize molecular interaction partners together within separated non-membrane-bound regions. It is unknown whether this strategy is used to facilitate protein degradation at specific locations within the cell. Leveraging in situ cryo-electron tomography to image the native molecular landscape of the unicellular alga

Indexed as

ProteolysisChlamydomonas reinhardtiiCryoelectron MicroscopyCytosolEndopeptidasesEndoplasmic ReticulumEndoplasmic Reticulum-Associated DegradationOptical ImagingProteasome Endopeptidase ComplexRibosomesValosin Containing ProteinEndopeptidasesProteasome Endopeptidase ComplexValosin Containing Proteincdc48cryo-electron tomographyERADphase separationproteasome

Identifiers

PMID31882451
PMCPMC6969544
OpenAlexW2996870716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.