Evidence map›Paper›PMID 31882445›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Multimodal transcriptional control of pattern formation in embryonic development.

Nicholas C Lammers, Vahe Galstyan, Armando Reimer, Sean A Medin, Chris H Wiggins, Hernan G Garcia

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 120 citations in OpenAlex.

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  16. Unified bursting strategies in ectopic and endogenousbioRxiv : the preprint server for biology · 2024
    Article
  17. Dynamic microenvironments shape nuclear organization and gene expression.Current opinion in genetics & development · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nicholas C LammersBiophysics Graduate Group, University of California, Berkeley, CA 94720.ORCID 0000-0001-6832-6152
Vahe GalstyanBiochemistry and Molecular Biophysics Option, California Institute of Technology, Pasadena, CA 91126.
Armando ReimerBiophysics Graduate Group, University of California, Berkeley, CA 94720.
Sean A MedinDepartment of Physics, University of California, Berkeley, CA 94720.
Chris H WigginsDepartment of Applied Physics and Applied Mathematics, Columbia University, New York, NY 10027; hggarcia@berkeley.edu chris.wiggins@columbia.edu.
Hernan G GarciaBiophysics Graduate Group, University of California, Berkeley, CA 94720; hggarcia@berkeley.edu chris.wiggins@columbia.edu.
University of California, Berkeley · USCalifornia Institute of Technology · USColumbia University · USQB3 · US

Funding

GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
Topology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4M
MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008295 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HURLEY, JAMES H, WEMMER, DAVID E · 1989 to 2022
$8.1M
Lighting Up the Central Dogma in Embryonic DevelopmentDP2HD094655 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI GARCIA, HERNAN GUSTAVO · 2017 to 2017
$2.4M
DEVELOPMENT OF GENOMIC INSTRUMENTATIONK22HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA IRVINE · PI BRODY, JAMES P · 2000 to 2004
$964k
NCI NIH HHS U54 CA193313NHGRI NIH HHS K22 HG000047NHGRI NIH HHS T32 HG000047NICHD NIH HHS DP2 HD094655NIGMS NIH HHS T32 GM008295
6 · The paper itself

Abstract

Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental outcomes remains an open challenge in physical biology. Using stripe 2 of the

Indexed as

AnimalsCell NucleusDrosophilaDrosophila ProteinsEmbryonic DevelopmentEmbryo, NonmammalianFemaleGene Expression Regulation, DevelopmentalGenes, InsectMaleModels, BiologicalRNA, MessengerTranscription FactorsTranscription, GeneticDrosophila ProteinsRNA, MessengerTranscription Factorsdevelopmentgene regulationhidden Markov modelstranscriptional bursting

Identifiers

PMID31882445
PMCPMC6969519
OpenAlexW2998186233

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.