Evidence map›Paper›PMID 31882397›Full record

ArticleLife science alliance2020

TRAP1 chaperone protein mutations and autoinflammation.

Ariane Si Standing, Ying Hong, Coro Paisan-Ruiz, Ebun Omoyinmi, Alan Medlar, Horia Stanescu, Robert Kleta, Dorota Rowcenzio, Philip Hawkins, Helen Lachmann and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. TRAP1 in Oxidative Stress and Neurodegeneration.Antioxidants (Basel, Switzerland) · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Ariane Si StandingUniversity College London and Great Ormond Street Institute of Child Health, London, UK ariane.standing@ucl.ac.uk.ORCID https://orcid.org/0000-0002-7178-4274
Ying HongUniversity College London and Great Ormond Street Institute of Child Health, London, UK.
Coro Paisan-RuizDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID https://orcid.org/0000-0002-1856-634X
Ebun OmoyinmiUniversity College London and Great Ormond Street Institute of Child Health, London, UK.
Alan MedlarUniversity College London Division of Medicine, London, UK.
Horia StanescuUniversity College London Division of Medicine, London, UK.
Robert KletaUniversity College London Division of Medicine, London, UK.
Dorota RowcenzioNational Amyloidosis Centre and Royal Free Hospital, London, UK.
Philip HawkinsNational Amyloidosis Centre and Royal Free Hospital, London, UK.
Helen LachmannNational Amyloidosis Centre and Royal Free Hospital, London, UK.
Michael F McDermottLeeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK.ORCID https://orcid.org/0000-0002-1015-0745
Despina EleftheriouUniversity College London and Great Ormond Street Institute of Child Health, London, UK.
Nigel KleinUniversity College London and Great Ormond Street Institute of Child Health, London, UK.
Paul A BroganUniversity College London and Great Ormond Street Institute of Child Health, London, UK.
Great Ormond Street Hospital · GBThe Royal Free Hospital · GBUniversity College London · GBIcahn School of Medicine at Mount Sinai · USNatural History Museum · GBSt James's University Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We identified a consanguineous kindred, of three affected children with severe autoinflammation, resulting in the death of one sibling and allogeneic stem cell transplantation in the other two. All three were homozygous for

Indexed as

MutationPhenotypeAdolescentAdultChildChild, PreschoolConsanguinityFatal OutcomeFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHereditary Autoinflammatory DiseasesHSP90 Heat-Shock ProteinsHumansInfantInfant, NewbornHSP90 Heat-Shock ProteinsIL18 protein, humanInterleukin-18MEFV protein, humanPyrinTRAP1 protein, human

Identifiers

PMID31882397
PMCPMC6975284
OpenAlexW2998723914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.