ArticleImmunity2020
Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells.
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In one paragraph
Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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62citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- From mechanism to therapy: advances in macrophage polarisation and targeted intervention in osteosarcoma.Frontiers in immunology · 2026Pooled it
- Spatial and functional specialization of human splenic innate lymphoid cells.Nature communications · 2026Article
- The long non-coding RNAeLife · 2026Article
- Article
- The development of innate lymphoid cells.Nature immunology · 2026Review
- Tfam-mediated metabolic perturbation in RORγtCell reports · 2026Article
- Mucosal Remodeling in Chronic Rhinosinusitis with Nasal Polyps: The Role of Innate Lymphoid Cells and Reprogramming Under IL-4Rα Blockade.International journal of molecular sciences · 2026Review
- The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.Frontiers in immunology · 2026Review
- Effect of Xuanfei Tongqiao acupuncture on nasal inflammation in rats with allergic rhinitis: modulation of long non-coding RNA growth arrest-specific transcript 5 methylation modification.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors.Immunity · 2025Article
- BACH2 drives the development and function of group 2 innate lymphoid cells.Science advances · 2025Article
- The transcription factor IRF4 regulates the homeostasis and function of intestinal ILC3s.iScience · 2025Article
- ILC2 Diversity, Location, and Function in Pulmonary Disease.Immunological reviews · 2025Review
- Spatial mapping of innate lymphoid cells in human lymphoid tissues and lymphoma at single-cell resolution.Nature communications · 2025Article
- Deciphering the Role of Innate Lymphoid Cells Group 3 in the Gut Microenvironment: A Narrative Review of Their Novel Contributions to Autoimmune Disease Pathogenesis.Journal of inflammation research · 2025Review
- Unraveling NK cell heterogeneity through single-cell sequencing: insights from physiological and tumor contexts for clinical applications.Frontiers in immunology · 2025Review
- Single-Cell Analysis: A Method for In-Depth Phenotyping of Cells Involved in Asthma.International journal of molecular sciences · 2024Review
- Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024Review
- Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors.Nature communications · 2024Article
- Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling.Developmental cell · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 3 countries.
Chao ZhongLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing 100191, PRC. Electronic address: zhongc@hsc.pku.edu.cn.
Mingzhu ZhengLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kairong CuiLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Andrew J MartinsLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Gangqing HuLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Dan LiLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, PRC; Department of Clinical Laboratory, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, PRC.
Lino TessarolloMouse Cancer Genetics Program, Center for Cancer Research, NCI, Frederick, MD 21702, USA.
Serguei KozlovCenter for Advanced Preclinical Research, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Jonathan R KellerMouse Cancer Genetics Program, Center for Cancer Research, NCI, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
John S TsangLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Keji ZhaoLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jinfang ZhuLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jfzhu@niaid.nih.gov.
National Heart Lung and Blood Institute · USFrederick National Laboratory for Cancer Research · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USCenter for Cancer Research · USPeking University · CNZhejiang University · CN
Funding
Transcriptional Regulation of Immune Cell Development, Activation and FunctionsZIAAI001169 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHU, JINFANG · 2012 to 2025
$21.8MMolecular-Cellular Regulation of Hematopoietic Stem CellsZIABC010001 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KELLER, JONATHAN R · 2009 to 2024
$16.8MEpigenetic Regulation of Hematopoietic Stem CellsZIAHL006031 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$16.6MEpigenetic Regulation of T cell differentiationZIAHL006030 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ZHAO, KEJI · 2009 to 2025
$15.3MIntegrative analysis and modeling of human immune responses and pathologiesZIAAI001152 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2022
$14.1MGene Targeting FacilityZICBC011265 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TESSAROLLO, LINO · 2010 to 2025
$8.9MSystems biology of macrophage activation and plasticity - from single cells to information propagation in networksZIAAI001143 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TSANG, JOHN · 2011 to 2020
$4.0MCCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA AI001169Intramural NIH HHS ZIA HL006031NCI NIH HHS HHSN261200800001E
Abstract
Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF. Here, we examined transcription factor(s) determining the fate of LTi progenitors versus non-LTi ILC progenitors. Conditional deletion of Gata3 resulted in the loss of PLZF
Indexed as
AnimalsCell LineageCells, CulturedGATA3 Transcription FactorInhibitor of Differentiation Protein 2Interleukin Receptor Common gamma SubunitMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group F, Member 3Programmed Cell Death 1 ReceptorPromyelocytic Leukemia Zinc Finger ProteinStem CellsT-Lymphocytes, Helper-InducerT-Lymphocyte SubsetsGata3 protein, mouseGATA3 Transcription FactorIdb2 protein, mouseIl2rg protein, mouseInhibitor of Differentiation Protein 2Interleukin Receptor Common gamma SubunitNuclear Receptor Subfamily 1, Group F, Member 3Pdcd1 protein, mouseProgrammed Cell Death 1 ReceptorPromyelocytic Leukemia Zinc Finger ProteinRorc protein, mouseZbtb16 protein, mousecell fate bifurcationgene expressioninnate lymphoid celllineage commitmentlymphocyte developmentlymphoid tissue inducerlymphopoiesisprogenitor heterogeneitytranscriptional regulationtranscription factor
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