Evidence map›Paper›PMID 31881992›Full record

ArticleTrials2019

Evaluation of bladder stimulation as a non-invasive technique for urine collection to diagnose urinary tract infection in infants under 6 months: a randomized multicenter study ("EE-Sti.Ve.N").

D Demonchy, C Ciais, E Fontas, E Berard, J Bréaud, P S Rohrlich, F Dubos, C Fortier, J Desmontils, A L Hérisse and 3 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03801213 (Evaluation of the Bladder Stimulation, a Non-invasive Technique of Urine Collection, in Infant Less Than 6 Months to Diagnose Urinary Tract Infection), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03801213 nacompletednot on this map

Evaluation of the Bladder Stimulation, a Non-invasive Technique of Urine Collection, in Infant Less Than 6 Months to Diagnose Urinary Tract Infection: a Randomized Multicenter Study

TypeinterventionalSponsorFondation LenvalRan2019 to 2023Enrolled170ConditionsUrinary Tract Infection BacterialArmsurinary catheterization, manual bladder stimulation technique
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

D DemonchyPediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France. demonchy.d@pediatrie-chulenval-nice.fr.ORCID http://orcid.org/0000-0003-1103-9894
C CiaisPediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
E FontasDélégation à la Recherche Clinique et à l'Innovation, Université Côté d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.
E BerardPediatric Nephrology Unit, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.
J BréaudDepartment of Pediatric Surgery, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
P S RohrlichDepartment of Hematology, Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.
F DubosPediatric Emergency Unit and Infectious Diseases, Université de Lille, Centre Hospitalier Universitaire de Lille, Lille, France.
C FortierDepartment of Pediatrics, Centre Hospitalier Général d'Antibes, Antibes, France.
J DesmontilsDepartment of Pediatrics, Centre Hospitalier Général de Grasse, Grasse, France.
A L HérissePediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
D DonzeauDélégation à la Recherche Clinique et à l'Innovation, Université Côté d'Azur, Centre Hospitalier Universitaire de Nice, Nice, France.
H HaasPediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
A TranPediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France.
Fondation Lenval · FRUniversité Côte d'Azur · FRCentre Procédés, Energies Renouvelables et Systèmes Energétiques · FRUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFebrile urinary tract infection (UTI) is common in infants and needs to be diagnosed quickly. However, the symptoms are non-specific, and diagnosis can only be confirmed after high quality urinalysis. The American Academy of Pediatrics recommends suprapubic aspiration (1-9% contamination) and urinary catheterization (8-14% contamination) for urine collection but both these procedures are invasive. Recent studies have shown a new non-invasive method of collecting urine, bladder stimulation, to be quick and safe. However, few data about bacterial contamination rates have been published for this technique. We hypothesize that the contamination rate of urine collection by bladder stimulation to diagnose febrile UTI in infants under 6 months is equivalent to that of urinary catheterization. METHODS/

designThis trial aims to assess equivalence in terms of bacterial contamination of urinary samples collected by urinary catheterization and bladder stimulation to diagnose UTI. Seven hundred seventy infants under 6 months presenting with unexplained fever in one of four Pediatric Emergency Departments in France will be enrolled. Each child will be randomized into a bladder stimulation or urinary catheterization group. The primary endpoints will be the validity of the urine sample assessed by the presence of contamination on bacterial culture.

conclusionA high recruitment rate is achievable due to the high prevalence of suspected UTIs in infants. The medical risk is the same as that for routine clinical care as we analyze patients with isolated fever. If our hypothesis holds true and the rate of urine contamination collected by bladder stimulation is acceptable, the infants included in the study will have benefited from a non-invasive and reliable means of collecting urine.

trial registrationClinicalTrials.gov, NCT03801213. Registered on 11 January 2019.

Indexed as

Emergency Service, HospitalHumansInfantMulticenter Studies as TopicPhysical StimulationRandomized Controlled Trials as TopicResearch DesignUrinalysisUrinary BladderUrinary CatheterizationUrinary Tract InfectionsUrineUrine Specimen CollectionBladder stimulationContaminationFeasibility studyInfantUrinary tract infectionUrine specimen collection

Identifiers

PMID31881992
PMCPMC6935056
OpenAlexW2997388333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.