ArticleBMC pediatrics2019
Autism spectrum disorder is associated with gut microbiota disorder in children.
Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Microbial dysbiosis as a diagnostic marker in psychiatric disorders: a systematic review of gut-brain axis disruptions.Frontiers in neuroscience · 2026Pooled it
- Alterations in gut microbiota composition in neurodevelopmental disorders: a systematic review and meta-analysis.Frontiers in microbiology · 2025Pooled it
- Microbiota in Autism Spectrum Disorder: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- A comparison between children and adolescents with autism spectrum disorders and healthy controls in biomedical factors, trace elements, and microbiota biomarkers: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- The Role of Gut Microbiota in Neuropsychiatric Diseases - Creation of An Atlas-Based on Quantified Evidence.Frontiers in cellular and infection microbiology · 2022Pooled it
- Gut Microbiota in Psychiatric Disorders: A Systematic Review.Psychosomatic medicine · 2021Pooled it
- Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression.Nutrients · 2026Article
- Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder.Gut microbes · 2025Review
- The Microbial Factors, Trace Elements, and Important Biological Indicators in Children with Autism Spectrum Disorder: A Meta-Analysis.Iranian journal of public health · 2025Review
- Associations between the gut microbiota at one-year and neurodevelopment in children from the SEPAGES cohort.Brain, behavior, & immunity - health · 2025Article
- Article
- Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota.Scientific reports · 2025Article
- Gut microbiota diversity affects fish behaviour and is influenced by host genetics and early rearing conditions.Open biology · 2025Article
- Exploring the Relationship Between Sporadic Creutzfeldt-Jakob Disease and Gut Microbiota Through a Mendelian Randomization Study.Molecular neurobiology · 2025Article
- Causal relationship between the gut microbiota and insomnia: a two-sample Mendelian randomization study.Frontiers in cellular and infection microbiology · 2024Article
- Effects and microbiota changes following oral lyophilized fecal microbiota transplantation in children with autism spectrum disorder.Frontiers in pediatrics · 2024Article
- The Dose-Response Effect of Fluoride Exposure on the Gut Microbiome and Its Functional Pathways in Rats.Metabolites · 2023Article
- From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes.Biomedicines · 2023Review
- Fatty acid metabolism changes in association with neurobehavioral deficits in animal models of fetal alcohol spectrum disorders.Communications biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate the occurrence and clinical characteristics of autism spectrum disorder (ASD) associated to the stable state of the gut microbiota.
methodsA total of 9 children with ASD and 6 healthy children used as control were selected and feces samples were collected from all of them. The 16S gene ribosomal RNA sequencing was used to analyze the difference in gut microbiota between healthy control children and ASD patients.
resultsThe results of 16S sequencing based on operational taxonomic units (OTUs) analysis showed that the ASD group and the healthy control (HC) group had a large difference in the abundance of microbiota at the level of family, genus and species. The abundance of Bacteroidales and Selenomonadales was significantly lower in the ASD group than in the HC group (p = 0.0110 and p = 0.0076, respectively). The abundance of Ruminococcaceae in the ASD group was higher than that in the HC group (p = 0.0285), while the amount of Prevotellaceae was significantly lower in the ASD group than in the HC group (p = 0.0111). The Tax4Fun analysis based on Kyoto Encyclopaedia of Genes and Genomes (KEGG) data indicated differentially expressed functional pathway between the ASD group and healthy control group associated to the nervous system, environmental information processing and cellular processing.
conclusionsThe abundance of gut microbiota in the ASD group is different from that in the healthy control children. These differences affect the biological function of the host. These results suggest that a disorder in the gut microbiota may be associated, at least in part, with ASD in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.