Evidence map›Paper›PMID 31881940›Full record

ArticleBMC endocrine disorders2019

The association of circulating irisin with metabolic risk factors in Chinese adults: a cross-sectional community-based study.

Lizhi Tang, Yuzhen Tong, Fang Zhang, Guilin Chen, Yun Cong Zhang, John Jobin, Nanwei Tong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Myokines in Acromegaly: An Altered Irisin Profile.Frontiers in endocrinology · 2021
    Article
  13. Article
  14. Irisin in Liver Cirrhosis.Journal of clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lizhi TangDivision of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, China.
Yuzhen TongBrescia University College, Western University, London, Ontario, Canada.
Fang ZhangDivision of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, China.
Guilin ChenWest China School of Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yun Cong ZhangCollege of medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
John JobinDivision of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, China.
Nanwei TongDivision of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxuexiang, Chengdu, 610041, Sichuan, China. tongnw@scu.edu.cn.ORCID http://orcid.org/0000-0002-5395-3660
Sichuan University · CNUniversity of Saskatchewan · CAWestern University · CA

Funding

National Natural Science Foundation of China 81700740
6 · The paper itself

Abstract

backgroundIrisin is a myokine that leads to increased energy expenditure by stimulating the browning of white adipose tissue. We aimed to investigate the association of serum irisin levels with metabolic parameters in middle aged Chinese population.

methodsThe study was based on a cross-sectional analysis of data from 524 nondiabetic subjects aged 40~65. All participants were recruited from a screening survey for Metabolic Syndrome in a community in Southwest China, including 294 subjects categorized as overweight (defined as BMI≧25 kg/m

resultsSerum irisin levels were significantly lower in nondiabetic overweight subjects compared with control (11.46 ± 4.11vs14.78 ± 7.03 μg/mL, p = 0.02). Circulating irisin was positively correlated with quantitative insulin sensitivity check index (QUICKI, r = 0.178, p = 0.045) and triglycerides (r = 0.149, p = 0.022); while irisin was negatively correlated with waist circumference (WC, r = - 0.185, p = 0.037), waist-to-hip ratio (WHR, r = - 0.176, p = 0.047), fasting insulin (r = - 0.2, p = 0.024), serum creatinine (r = - 0.243, p = 0.006), homeostasis model assessment for insulin resistance (HOMA-IR, r = - 0.189, p = 0.033). Multiple linear regression showed that irisin was inversely associated with HOMA-IR (β = - 0.342 ± 0.154, p = 0.029). Higher irisin was associated with decreased odds of being overweight (OR = 0.281, β = - 1.271, p = 0.024).

conclusionsWe found that serum irisin levels were lower in overweight subjects. Moreover, serum irisin levels were inversely correlated with adverse metabolic parameters including WC, WHR, creatinine, HOMA-IR and fasting insulin, suggesting that irisin may play a role in obesity related insulin resistance.

Indexed as

AdultAgedBody Mass IndexChinaCross-Sectional StudiesFemaleFibronectinsHumansMaleMetabolic SyndromeMiddle AgedObesityOverweightRisk FactorsFibronectinsFNDC5 protein, humanInsulin resistanceIrisinMyokinesObesity

Identifiers

PMID31881940
PMCPMC6935078
OpenAlexW2996941833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.