ArticleParasites & vectors2019
Genetic variation of Echinococcus spp. in yaks and sheep in the Tibet Autonomous Region of China based on mitochondrial DNA.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 30 citations in OpenAlex.
- Genetic diversity, haplotype structure, and population dynamics of Echinococcus granulosus isolates from human cystic echinococcosis in Tibet, China.Tropical medicine and health · 2026Article
- Five-Year Slaughterhouse-Based Surveillance ofPathogens (Basel, Switzerland) · 2025Article
- Article
- Assembly, Annotation, and Comparative Analysis of Mitochondrial Genomes inInternational journal of molecular sciences · 2024Article
- First report of Echinococcus granulosus genotype 1 in a wild boar (Sus scrofa) from China.Parasitology research · 2024Article
- First Case Report of Cystic Echinococcosis Caused by G7 GenotypeChina CDC weekly · 2024Article
- Update on the genetic diversity and population structure of Echinococcus granulosus in Gansu Province, Tibet Autonomous Region, and Xinjiang Uygur Autonomous Region, Western China, inferred from mitochondrial cox1, nad1, and nad5 sequences.Parasitology research · 2023Article
- Cystic echinococcosis in donkeys in eastern Africa.Parasitology · 2023Article
- Echinococcus spp. and genotypes infecting humans in Tibet Autonomous Region of China: a molecular investigation with near-complete/complete mitochondrial sequences.Parasites & vectors · 2022Article
- Food-borne zoonotic echinococcosis: A review with special focus on epidemiology.Frontiers in veterinary science · 2022Review
- Genetic diversity and haplotype analysis of yak and sheep echinococcal cysts isolates from the mitochondrialFrontiers in veterinary science · 2022Article
- Article
- The Molecular Epidemiology ofPathogens (Basel, Switzerland) · 2020Review
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13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCystic echinococcosis (CE) in humans and livestock is caused by Echinococcus granulosus (sensu lato). In China where CE is endemic, a number of studies have shown that Echinococcus granulosus (sensu stricto) is majorly responsible for CE. However, E. canadensis (G6) which is the second leading cause of CE is now being detected in most parts of the country. In this study, the species diversity and genetic variation of Echinococcus granulosus (s.l.) in four counties in Tibet Autonomous Region of China were investigated.
methodsInfection with Echinococcus granulosus (s.s.) in yaks and sheep was identified using NADH dehydrogenase subunit 1 and 5 (nad1 and nad5) mitochondrial genes while the genotype G6 of E. canadensis initially diagnosed with NADH dehydrogenase subunit 1 (nad1) was further confirmed by analysis of the complete mitochondrial genome and a phylogenetic network constructed based on the nad2 and nad5 genes.
resultsOut of 85 hydatid cyst samples collected from slaughtered sheep (n = 54) and yaks (n = 31), 83 were identified as E. granulosus (s.s.) G1 (n = 77), G3 (n = 6) and 2 were identified as E. canadensis G6. Analysis of the nad1/nad5 genes revealed 16/17 mutations with 9/14 parsimony informative sites resulting in 15/14 haplotypes, respectively. Haplotype diversity (Hd) and nucleotide diversity (π) of E. granulosus (s.s.) population were 0.650 and 0.00127 for nad1 and 0.782 and 0.00306 for nad5, respectively, with an overall negative Tajima's D and Fu's Fs. A low F
conclusionPockets of infection with E. canadensis (G6, G7, G8 and G10) have been previously reported in sheep, goats, yaks and/or humans in different parts of China. While the G6 genotype has been previously reported in sheep in the Tibet Autonomous Region, the detection in a yak in the present study represents the first to the best of our knowledge. Therefore, we recommend future surveys and control efforts to comprehensively investigate other potential intermediate hosts for the prevalence and genetic diversity of the E. canadensis group (G6, G7, G8 and G10) across the country and their inclusion into the existing CE control programme.
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