ArticleMolecules (Basel, Switzerland)2019
Ketoprofen-Based Ionic Liquids: Synthesis and Interactions with Bovine Serum Albumin.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- A Fast HPLC/UV Method for Determination of Ketoprofen in Cellular Media.ChemistryOpen · 2024Article
- Potential for cardiac toxicity with methylimidazolium ionic liquids.Ecotoxicology and environmental safety · 2023Article
- New amino acid propyl ester ibuprofenates from synthesis to use in drug delivery systems.RSC advances · 2022Article
- Isopropyl Amino Acid Esters Ionic Liquids as Vehicles for Non-Steroidal Anti-Inflammatory Drugs in Potential Topical Drug Delivery Systems with Antimicrobial Activity.International journal of molecular sciences · 2022Article
- Salicylic Acid as Ionic Liquid Formulation May Have Enhanced Potency to Treat Some Chronic Skin Diseases.Molecules (Basel, Switzerland) · 2021Article
- Novel Naproxen Salts with Increased Skin Permeability.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The development of ionic liquids based on active pharmaceutical ingredients (API-ILs) is a possible solution to some of the problems of solid and/or hydrophobic drugs such as low solubility and bioavailability, polymorphism and an alternative route of administration could be suggested as compared to the classical drug. Here, we report for the first time the synthesis and detailed characterization of a series of ILs containing a cation amino acid esters and anion ketoprofen (KETO-ILs). The affinity and the binding mode of the KETO-ILs to bovine serum albumin (BSA) were assessed using fluorescence spectroscopy. All compounds bind in a distance not longer than 6.14 nm to the BSA fluorophores. The estimated binding constants (KA) are in order of 10
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