ArticleBritish journal of pharmacology2020
Cell-permeable high-affinity tracers for G
Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy.Chemical science · 2024Article
- Recommended Tool Compounds: Application of YM-254890 and FR900359 to Interrogate GαACS pharmacology & translational science · 2023Review
- The Bacterial GJournal of chemical ecology · 2023Article
- Article
- Imaging of GαPharmaceutics · 2022Article
- Agonist-Dependent Coupling of the Promiscuous Adenosine AACS pharmacology & translational science · 2022Article
- Targeting Oncogenic GαCancers · 2021Review
- β2-adrenergic receptor regulates ER-mitochondria contacts.Scientific reports · 2021Article
- Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?ACS pharmacology & translational science · 2021Article
- Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359.Nature communications · 2021Article
- Functional characterization of uveal melanoma oncogenes.Oncogene · 2021Article
- Heterotrimeric GThe Journal of biological chemistry · 2020Review
- Cell-permeable high-affinity tracers for GBritish journal of pharmacology · 2020Article
- Sensitive LC-MS/MS Method for the Quantification of Macrocyclic GαFrontiers in chemistry · 2020Article
- An experimental strategy to probe Gq contribution to signal transduction in living cells.The Journal of biological chemistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeG proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The G EXPERIMENTAL APPROACH: We have now developed G KEY
resultsFR and YM displayed low nanomolar affinity for Gα CONCLUSIONS AND IMPLICATIONS: The Gq protein inhibitors YM and FR are pharmacologically different despite similar structures. The new versatile tools and powerful assays will contribute to the advancement of the rising field of G protein research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.