ArticleEnvironmental toxicology and chemistry2020
Best Practices for Derivation and Application of Thresholds for Metals Using Bioavailability-Based Approaches.
Article in Environmental toxicology and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Development of Fluoride Protective Values for Aquatic Life Using Empirical Bioavailability Models.Environmental toxicology and chemistry · 2022Pooled it
- Time and contamination level dependence of metal bioaccumulation and multibiomarker responses in fish: implications for biomonitoring.Environmental monitoring and assessment · 2026Article
- Review
- Comparative Performance of Multiple Linear Regression and Biotic Ligand Models for Estimating the Bioavailability of Copper in Freshwater.Environmental toxicology and chemistry · 2021Article
- Application of Bioavailability Models to Derive Chronic Guideline Values for Nickel in Freshwaters of Australia and New Zealand.Environmental toxicology and chemistry · 2021Article
- Deriving a bioavailability-based zinc environmental quality standard for France.Environmental science and pollution research international · 2021Article
- Validation of Bioavailability-Based Toxicity Models for Metals.Environmental toxicology and chemistry · 2020Review
- Development of Empirical Bioavailability Models for Metals.Environmental toxicology and chemistry · 2020Article
- State of the Science on Metal Bioavailability Modeling: Introduction to the Outcome of a Society of Environmental Toxicology and Chemistry Technical Workshop.Environmental toxicology and chemistry · 2020Article
- Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review.Environmental toxicology and chemistry · 2020Review
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
Abstract
The primary goal of the present study is to provide a broad view of best practices for evaluating bioavailability models for metals for use in the protection of aquatic life. We describe the state of the science regarding 1) the evaluation and selection of ecotoxicity data, 2) the selection of bioavailability models for use in normalization, and 3) subsequent application of bioavailability models. Although many examples of normalization steps exist worldwide, a scheme is proposed to evaluate and select a model that takes account of its representativeness (water chemistry and taxonomic coverage of the ecotoxicity data set) and validation performance. Important considerations for a suitable model are the quantity of inputs needed, accuracy, and ease of use, all of which are needed to set protective values for aquatic life and to use these values to evaluate potential risks to organisms in receiving waters. Although the end results of different model application approaches may be broadly similar, the differences in these application frameworks ultimately come down to a series of trade-offs between who needs to collect the data and use the bioavailability model, the different requirements of spatial scales involved (e.g., regional vs site-specific values), and model predictiveness and protectiveness. Ultimately, understanding the limits and consequences of these trade-offs allows for selection of the most appropriate model and application framework to best provide the intended levels of aquatic life protection. Environ Toxicol Chem 2019;39:118-130. © 2019 SETAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.