ReviewEnvironmental toxicology and chemistry2020
Validation of Bioavailability-Based Toxicity Models for Metals.
Review in Environmental toxicology and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development of Fluoride Protective Values for Aquatic Life Using Empirical Bioavailability Models.Environmental toxicology and chemistry · 2022Pooled it
- Proposal of novel Predicted No Effect Concentrations (PNEC) for metals in freshwater using Species Sensitivity Distribution for different taxonomic groups.Scientific reports · 2025Article
- Development of a bioavailability-based acute effects assessment method for nickel.Environmental toxicology and chemistry · 2025Article
- The lab-field continuum in conservation physiology research: leveraging multiple approaches to inform policy and practice.Conservation physiology · 2025Article
- Variation in chronic nickel toxicity to Daphnia magna among Japanese river waters and performance evaluation of bioavailability models in predicting the toxicity.Environmental science and pollution research international · 2022Article
- Development of a bioavailability-based risk assessment framework for nickel in Southeast Asia and Melanesia.Integrated environmental assessment and management · 2021Article
- Comparative Performance of Multiple Linear Regression and Biotic Ligand Models for Estimating the Bioavailability of Copper in Freshwater.Environmental toxicology and chemistry · 2021Article
- Application of Bioavailability Models to Derive Chronic Guideline Values for Nickel in Freshwaters of Australia and New Zealand.Environmental toxicology and chemistry · 2021Article
- Mean Species Abundance as a Measure of Ecotoxicological Risk.Environmental toxicology and chemistry · 2020Article
- Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review.Environmental toxicology and chemistry · 2020Review
- Development of Empirical Bioavailability Models for Metals.Environmental toxicology and chemistry · 2020Article
- State of the Science on Metal Bioavailability Modeling: Introduction to the Outcome of a Society of Environmental Toxicology and Chemistry Technical Workshop.Environmental toxicology and chemistry · 2020Article
- Best Practices for Derivation and Application of Thresholds for Metals Using Bioavailability-Based Approaches.Environmental toxicology and chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Regulatory jurisdictions worldwide are increasingly incorporating bioavailability-based toxicity models into development of protective values (PVALs) for freshwater and saltwater aquatic life (e.g., water quality criteria, standards, and/or guidelines) for metals. Use of such models for regulatory purposes should be contingent on their ability to meet performance criteria as specified through a model-validation process. Model validation generally involves an assessment of a model's appropriateness, relevance, and accuracy. We review existing guidance for validation of bioavailability-based toxicity models, recommend questions that should be addressed in model-validation studies, discuss model study type and design considerations, present several new ways to evaluate model performance in validation studies, and suggest a framework for use of model validation in PVAL development. We conclude that model validation should be rigorous but flexible enough to fit the user's purpose. Although a model can never be fully validated to a level of zero uncertainty, it can be sufficiently validated to fit a specific purpose. Therefore, support (or lack of support) for a model should be presented in such a way that users can choose their own level of acceptability. We recommend that models be validated using experimental designs and endpoints consistent with the data sets that were used to parameterize and calibrate the model and validated across a broad range of geographically and ecologically relevant water types. Environ Toxicol Chem 2019;39:101-117. © 2019 SETAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.