SynthesisMedicina oral, patologia oral y cirugia bucal2020
The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Damage of irradiated teeth by ultrasonic scaling: an in vitro study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Role of diode laser (810 nm) and/or fluoride varnish for the treatment of gamma-irradiated hypersensitive human dentin (An in vitro study).Scientific reports · 2025Article
- Article
- The influence of different radiotherapy doses on the mechanical properties and microstructure of the enamel and dentin of human premolar teeth.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Assessment of multispecies biofilm growth on root canal dentin under different radiation therapy regimens.Clinical oral investigations · 2024Article
- Acid challenge exacerbates activation of matrix metalloproteinases in permanent teeth undergoing radiotherapy.Brazilian oral research · 2024Article
- Color stability and microhardness alteration of irradiated dental enamel treated with a high fluoride concentration toothpaste.Clinical oral investigations · 2022Article
- Toxicological Risks of the Cobalt-Chromium Alloys in Dentistry: A Systematic Review.Materials (Basel, Switzerland) · 2022Review
- Dosimetric Comparison between Volumetric Modulated Arc Therapy (VMAT) and Intensity-Modulated Radiotherapy (IMRT) for Dental Structures of Head and Neck Cancer Patients.Journal of healthcare engineering · 2022Article
- Activation of gelatinases in permanent human teeth after different experimental radiotherapy protocols.Brazilian dental journalArticle
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. MATERIAL AND
methodsSystematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory studies evaluating the effects of simulated or in vivo HNRT on the DEJ were included. The GRADE tool adapted for in vitro studies was used to assess the methodological quality.
resultsOf the 154 initially selected studies, eight met the inclusion criteria, from which five studies were graded as high quality of evidence, two studies were graded as moderate quality and one as low quality. Two studies did not demonstrate DEJ alterations following HNRT while the other six articles described several organic and inorganic changes in the DEJ of irradiated teeth samples. These radiogenic events were mostly detected through micro and nanoindentation, Raman micro-spectroscopy, confocal microscopy, Western blotting and optical coherence tomography.
conclusionsHNRT may have a negative impact on the physical and chemical aspects of the DEJ, predisposing cancer patients to RRC and enamel delamination.
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