Trial reportMedicina oral, patologia oral y cirugia bucal2020
Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions: a randomized controlled trial.
Trial report in Medicina oral, patologia oral y cirugia bucal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 7 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effects of Different Treatment Sequences on the Efficacy of Combined Periodontal-Endodontic Lesions: A Systematic Review and Meta-Analysis.International dental journal · 2026Pooled it
- Surgical interventions for endodontic-periodontal lesions: A Systematic Review without Meta-analysis (SWiM).Clinical oral investigations · 2025Pooled it
- Autogenous platelet concentrates for treatment of intrabony defects-A systematic review with meta-analysis.Periodontology 2000 · 2025Pooled it
- Regeneration of periodontal intrabony defects using platelet-rich fibrin (PRF): a systematic review and network meta-analysis.Odontology · 2024Pooled it
- Influence of the timing of periodontal intervention on periapical/periodontal repair in endodontic-periodontal lesions: a systematic review.Clinical oral investigations · 2023Pooled it
- Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: A systematic review and meta-analysis.F1000Research · 2023Pooled it
- Use of Platelet-Rich Fibrin in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis.BioMed research international · 2021Pooled it
- The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study.PloS one · 2024Trial
- Diabetes Mellitus and Endo-Periodontal Lesions: An HbA1c-Guided Framework for Clinical Decision-Making.Medicina (Kaunas, Lithuania) · 2026Review
- Scaffold-Based Biomaterials for Periodontal Regeneration in Periodontitis: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Review
- Polymerized injectable platelet-rich fibrin with octacalcium phosphate (bontree®) for treatment of periodontal intrabony defects assessed using CBCT: A randomized controlled clinical trial.Bioinformation · 2026Article
- Evaluating the antimicrobial efficacy, growth factor release drug kinetics of titanium platelet-rich fibrin loaded with amoxiclav, metronidazole and neem gel: anJournal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- Comparative Analysis of Local Application of Titanium-Platelet Rich Fibrin (T-PRF) and Leukocyte-Platelet Rich Fibrin (L-PRF) in Bone Defect Healing: A Micro-CT and Histopathological Study in Rabbit Models.Microscopy research and technique · 2025Article
- Management of the endodontic-periodontal lesion.British dental journal · 2025Review
- Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality.Journal of materials science. Materials in medicine · 2024Article
- Impact of Infrabony Defects Treatment on Periodontal Markers and Glycated Hemoglobin Using Platelet-Rich Fibrin, Guided Tissue Regeneration, and Access-Flap Surgery.Medicina (Kaunas, Lithuania) · 2024Article
- Endoperiodontal lesions: diagnosis first, then treatment and not always tooth extraction: a cross-sectional survey in Spain and a proposal of a clinical treatment protocol.Journal of clinical and experimental dentistry · 2024Article
- Regenerative Surgical Management of an Endodontic Periodontic Lesion of the Mandibular Molar Combined With External Inflammation Root Resorption.Case reports in dentistry · 2024Article
- Novel approaches to the use of platelet-rich fibrin: A literature review.The Saudi dental journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. MATERIAL AND
methodsA total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. The radiographic depth of IBD was also measured. Primary outcomes assessed were changes in PD, CAL, and radiographic IBD that were assessed at the beginning and nine months later. Results: The PRF and GTR group showed significant improvement in clinical parameters compared with the OFD alone (control group) at nine months. While there were no significant differences in PD and CAL between test groups (T-PRF and GTR groups), the significant difference was found in radiographic IBD depth.
conclusionT-PRF may give similar successful results as GTR in the treatment of IBDs with endo-perio lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.