ArticleJournal of clinical laboratory analysis2020
Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Selenoprotein S Deficiency Induces Matrix Degradation Via TGF-β Pathway Leading to Cartilage Damage.Biological trace element research · 2026Article
- Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination.Chinese medicine · 2025Article
- Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments.World journal of gastroenterology · 2023Article
- Role of lncRNAs in acute pancreatitis: pathogenesis, diagnosis, and therapy.Frontiers in genetics · 2023Review
- MALAT1 knockdown alleviates myocardial injury in mice with severe acute pancreatitis via the miR-374a/Sp1/Wnt/β-catenin pathway.American journal of translational research · 2023Article
- Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury.Bioengineering (Basel, Switzerland) · 2022Review
- Longitudinal variation of circulating Inc-ITSN1-2: A novel biomarker reflecting disease severity, inflammation, recurrence, and death risk in acute ischemic stroke patients.Journal of clinical laboratory analysis · 2022Article
- Blood long non-coding RNA intersectin 1-2 is highly expressed and links with increased Th17 cells, inflammation, multiple organ dysfunction, and mortality risk in sepsis patients.Journal of clinical laboratory analysis · 2022Article
- Endogenous tRNA-derived small RNA (tRF3-Thr-AGT) inhibits ZBP1/NLRP3 pathway-mediated cell pyroptosis to attenuate acute pancreatitis (AP).Journal of cellular and molecular medicine · 2021Article
- Cardiac indicator CK-MB might be a predictive marker for severity and organ failure development of acute pancreatitis.Annals of translational medicine · 2021Article
- Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis.Journal of clinical laboratory analysis · 2020Article
- Fibroblast Growth Factor (FGF) Signaling Protects Against Acute Pancreatitis-Induced Damage by Modulating Inflammatory Responses.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the predictive value of long non-coding RNA intersectin 1-2 (lnc-ITSN1-2) for severe acute pancreatitis (SAP) risk, and its correlation with disease severity and in-hospital mortality in SAP patients.
methodsPlasma samples from 60 SAP, 60 moderate-severe acute pancreatitis (MSAP) and 60 mild acute pancreatitis (MAP) patients were collected within 24 hours, and plasma samples from 60 age and gender-matched healthy controls (HCs) were collected when enrollment. Lnc-ITSN1-2 was detected by reverse transcription-quantitative polymerase chain reaction. In AP patients, disease severity was evaluated and in-hospital deaths were recorded.
resultsLnc-ITSN1-2 was increased in SAP patients compared with MSAP, MAP patients, and HCs, and it is well-discriminated SAP patients from MSAP patients (area under curve (AUC): 0.699, 95% confidence interval (CI): 0.605-0.792), MAP patients (AUC: 0.862, 95% CI: 0.798-0.926), and HCs (AUC: 0.958, 95% CI: 0.925-0.990). For disease severity, lnc-ITSN1-2 was positively correlated with Ranson's score, acute pathologic and chronic health evaluation (APACHE) II score, sequential organ failure assessment (SOFA) score, and C-reactive protein (CRP) in SAP patients, MSAP patients, and MAP patients; meanwhile, the correlation coefficients were highest in SAP patients. Furthermore, lnc-ITSN1-2 displayed a good predictive value for increased in-hospital mortality in SAP (AUC: 0.803, 95% CI: 0.673-0.933) and MSAP (AUC: 0.854, 95% CI: 0.752-0.956) patients, which was similar with several common prognostic factors (including Ranson's score, APACHE II score, SOFA score, and CRP).
conclusionLnc-ITSN1-2 might be a potential biomarker for discrimination of SAP to improve the prognosis of SAP patients.
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