ArticleJournal of clinical laboratory analysis2020
Middle- and high-molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Gut Microbiota Predicts Treatment Response to Empagliflozin Among MASLD Patients Without Diabetes Mellitus.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- [Prevalence rate and risk factor analysis of nonalcoholic fatty liver disease in 115 female patients with schizophrenia].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Osteocalcin and Its Potential Functions for Preventing Fatty Liver Hemorrhagic Syndrome in Poultry.Animals : an open access journal from MDPI · 2023Review
- Association between lower plasma adiponectin levels and higher liver stiffness in type 2 diabetic individuals with nonalcoholic fatty liver disease: an observational cross-sectional study.Hormones (Athens, Greece) · 2022Observational
- Data on Adiponectin from 2010 to 2020: Therapeutic Target and Prognostic Factor for Liver Diseases?International journal of molecular sciences · 2020Review
- Middle- and high-molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAdiponectin (APN) circulates as high-molecular weight (HMW), medium-molecular weight (MMW), and low-molecular weight (LMW) forms. Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Currently, the role of LMW, MMW, and HMW APN remains largely unclear in NAFLD.
methodsWe examined the variation of these forms and analyzed the related clinical characteristics in NAFLD. A total of 63 male NAFLD patients (mean age: 43.00 ± 6.10 years) and 70 healthy male subjects (mean age: 42.53 ± 7.98 years) were included in the study. Total APN and other clinical characteristics were measured. The changes in HMW, MMW, and LMW APN were determined in NAFLD patients and NAFLD patients on a high-fat diet, and the association between the groups was further analyzed.
resultsDecreased levels of total APN and three APN isoforms were found in NAFLD. Significantly decreased levels of HMW (P < .01) and MMW (P < .001) were observed in NAFLD of high-fat diet patients. In NAFLD patients, height (R = -.270, P = .032) and N-epsilon-(carboxymethyl) lysine (R = -.259, P = .040) significantly correlated with total APN. HMW APN was significantly associated with fasting plasma glucose (R = .350, P = .016), alanine aminotransferase (R = -.321, P = .029), and aspartate aminotransferase (R = -.295, P = .045). Additionally, MMW APN was significantly associated with total cholesterol (R = .357, P = .014) and high-density lipoprotein (R = .556, P < .0001). Low-density lipoprotein (R = -.283, P = .054) was also clearly associated with LMW APN in NAFLD patients.
conclusionThese results suggest that HMW and MMW APN may be involved in the pathogenesis and progression of NAFLD.
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