Evidence map›Paper›PMID 31879977›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2020

Girls' brain structural connectivity in late adolescence relates to history of depression symptoms.

Rajpreet Chahal, David G Weissman, Scott Marek, Shawn A Rhoads, Alison E Hipwell, Erika E Forbes, Kate Keenan, Amanda E Guyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Rajpreet ChahalDepartment of Human Ecology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-0985-5622
David G WeissmanDepartment of Psychology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-9966-3338
Scott MarekDepartment of Neurology, Washington University, St. Louis, MO, USA.ORCID 0000-0003-0032-9052
Shawn A RhoadsDepartment of Psychology, Georgetown University, Washington, DC, USA.ORCID 0000-0003-1350-9458
Alison E HipwellDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7179-1151
Erika E ForbesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0659-7744
Kate KeenanDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-1775-8171
Amanda E GuyerDepartment of Human Ecology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-1817-8766
University of California, Davis · USUniversity of Pittsburgh · USGeorgetown University · USHarvard University · USUniversity of Chicago · USWashington University in St. Louis · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
The Development of Conduct Disorder in GirlsR01MH056630 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOEBER, ROLF · 1998 to 2012
$18.9M
Developmental Changes in Neural Processes Underlying Inattention, Impulsivity and RegulationR01MH091068 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHWEITZER, JULIE B. · 2012 to 2022
$7.4M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
UC Davis CTSC TL1 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility MentorshipTL1TR001861 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2025
$4.7M
Development of Anhedonia in High-Risk AdolescentsR01MH104418 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORBES, ERIKA E · 2015 to 2020
$3.1M
Changes in brain function during adolescence and risk for depression in girlsR01MH093605 · NIMH · UNIVERSITY OF CHICAGO · PI FORBES, ERIKA E, GUYER, AMANDA E · 2011 to 2015
$2.9M
Preadolescent Precursors to Depression in GirlsR01MH066167 · NIMH · UNIVERSITY OF CHICAGO · PI KEENAN, KATHRYN ELIZABETH · 2004 to 2008
$2.6M
Characterizing neurodevelopmental trajectories of social-emotional processing circuitry in girls across adolescenceR03MH116519 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GUYER, AMANDA E · 2018 to 2019
$157k
NCATS NIH HHS TL1 TR001861NCATS NIH HHS UL1 TR001860NIMH NIH HHS R01 MH056630NIMH NIH HHS R01-MH056630NIMH NIH HHS R01 MH066167NIMH NIH HHS R01-MH066167NIMH NIH HHS R01 MH091068NIMH NIH HHS R01 MH093605NIMH NIH HHS R01-MH093605NIMH NIH HHS R01 MH104418NIMH NIH HHS R03 MH116519NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

backgroundGirls' depressive symptoms typically increase in adolescence, with individual differences in course and severity being key risk factors for impaired emotional functioning in young adulthood. Given the continued brain white matter (WM) maturation that occurs in adolescence, the present study tested whether structural connectivity patterns in late adolescence are associated with variation in the course of depression symptom severity throughout adolescence.

methodParticipants were girls (N = 115) enrolled in a multiyear prospective cohort study of risk for depression. Initial depression severity (intercept) at age 10 and change in severity (linear slope) across ages 10-19 were examined in relation to WM tractography collected at age 19. Network-based statistic analyses were used to identify clusters showing variation in structural connectivity in association with depressive symptom intercept, slope, and their interaction.

resultsHigher initial depressive severity and steeper positive slope (separately) were associated with greater structural connectivity between temporal, subcortical socioaffective, and occipital regions. Intercept showed more connectivity associations than slope. The interaction effect indicated that higher initial symptom severity and a steeper negative slope (i.e., alleviating symptoms) were related to greater connectivity between cognitive control regions. Moderately severe symptoms that worsened over time were followed by greater connectivity between self-referential and cognitive regions (e.g., posterior cingulate and frontal gyrus).

conclusionsHigher depressive symptom severity in early adolescence and increasing symptom severity over time may forecast structural connectivity differences in late adolescence, particularly in pathways involving cognitive and emotion-processing regions. Understanding how clinical course relates to neurobiological correlates may inform new treatment approaches to adolescent depression.

Indexed as

AdolescentBrainChildDepressionFemaleHumansProspective StudiesWhite MatterYoung AdultAdolescencebrain imagingconnectomicsdepressiondevelopment

Identifiers

PMID31879977
PMCPMC7316589
OpenAlexW2998125090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.