Evidence map›Paper›PMID 31879843›Full record

ReviewCerebellum (London, England)2020

Consensus Paper. Cerebellar Reserve: From Cerebellar Physiology to Cerebellar Disorders.

H Mitoma, A Buffo, F Gelfo, X Guell, E Fucà, S Kakei, J Lee, M Manto, L Petrosini, A G Shaikh and 1 more

Open access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Cerebellum (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 5 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 5 syntheses or guidelines pooled it, 150 citations in OpenAlex.

  1. Pooled it
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  16. Possible compensatory role of cerebellum in bipolar disorder. A cortical thickness study.European archives of psychiatry and clinical neuroscience · 2026
    Article
  17. Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026
    Review
  18. Article
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 4 countries.

H MitomaMedical Education Promotion Center, Tokyo Medical University, Tokyo, Japan. mitoma@tokyo-med.ac.jp.ORCID http://orcid.org/0000-0003-0513-1811
A BuffoDepartment of Neuroscience Rita Levi-Montalcini, University of Turin, 10126, Turin, Italy.
F GelfoDepartment of Human Sciences, Guglielmo Marconi University, 00193, Rome, Italy.
X GuellDepartment of Neurology, Massachusetts General Hospital, Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Harvard Medical School, Boston, USA.
E FucàDepartment of Neuroscience Rita Levi-Montalcini, University of Turin, 10126, Turin, Italy.
S KakeiTokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
J LeeKomatsu University, Komatsu, Japan.
M MantoUnité des Ataxies Cérébelleuses, Service de Neurologie, CHU-Charleroi, 6000, Charleroi, Belgium.
L PetrosiniIRCCS Fondazione Santa Lucia, 00179, Rome, Italy.
A G ShaikhLouis Stokes Cleveland VA Medical Center, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
J D SchmahmannDepartment of Neurology, Massachusetts General Hospital, Ataxia Unit, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Harvard Medical School, Boston, USA.
Harvard University · USNeuroscience Institute · ITFondazione Santa Lucia · ITKomatsu University · JPLouis Stokes Cleveland VA Medical Center · USMarconi University · ITTokyo Medical University · JPTokyo Metropolitan Institute of Medical Science · JPUniversity of Mons · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar reserve refers to the capacity of the cerebellum to compensate for tissue damage or loss of function resulting from many different etiologies. When the inciting event produces acute focal damage (e.g., stroke, trauma), impaired cerebellar function may be compensated for by other cerebellar areas or by extracerebellar structures (i.e., structural cerebellar reserve). In contrast, when pathological changes compromise cerebellar neuronal integrity gradually leading to cell death (e.g., metabolic and immune-mediated cerebellar ataxias, neurodegenerative ataxias), it is possible that the affected area itself can compensate for the slowly evolving cerebellar lesion (i.e., functional cerebellar reserve). Here, we examine cerebellar reserve from the perspective of the three cornerstones of clinical ataxiology: control of ocular movements, coordination of voluntary axial and appendicular movements, and cognitive functions. Current evidence indicates that cerebellar reserve is potentiated by environmental enrichment through the mechanisms of autophagy and synaptogenesis, suggesting that cerebellar reserve is not rigid or fixed, but exhibits plasticity potentiated by experience. These conclusions have therapeutic implications. During the period when cerebellar reserve is preserved, treatments should be directed at stopping disease progression and/or limiting the pathological process. Simultaneously, cerebellar reserve may be potentiated using multiple approaches. Potentiation of cerebellar reserve may lead to compensation and restoration of function in the setting of cerebellar diseases, and also in disorders primarily of the cerebral hemispheres by enhancing cerebellar mechanisms of action. It therefore appears that cerebellar reserve, and the underlying plasticity of cerebellar microcircuitry that enables it, may be of critical neurobiological importance to a wide range of neurological/neuropsychiatric conditions.

Indexed as

Adaptation, PhysiologicalAnimalsCerebellar DiseasesCerebellumEye MovementsHumansAutophagyCerebellar ataxiasCerebellar cognitive affective syndromeCerebellar reserveCerebellumDendritic spinesEnvironmental enrichmentEye movementNeuromodulation therapyPredictive controlSaccade

Identifiers

PMID31879843
PMCPMC6978437
OpenAlexW2998331521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.