ArticleEJNMMI physics2019
Towards standardization of absolute SPECT/CT quantification: a multi-center and multi-vendor phantom study.
Article in EJNMMI physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 93 citations in OpenAlex.
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- Quantitative capabilities of commercial CZT SPECT-CT cameras withEJNMMI physics · 2025Article
- Towards harmonized holmium-166 SPECT image quality for dosimetry: a multi-center, multi-vendor study.EJNMMI physics · 2025Article
- 360° CZT-SPECT/CT cameras:EJNMMI physics · 2024Article
- The value of quantitative analysis of radionuclide bone SPECT/CT imaging in vertebral compression fracture: a retrospective study.BMC medical imaging · 2024Article
- From SPECT/CT towards absolute quantification? - the case of unilateral condylar hyperplasia of the mandible.EJNMMI physics · 2024Article
- Performance evaluation of the 3D-ring cadmium-zinc-telluride (CZT) StarGuide system according to the NEMA NU 1-2018 standard.EJNMMI physics · 2024Article
- An international phantom study of inter-site variability in Technetium-99m image quantification: analyses from the TARGET radioembolization study.EJNMMI physics · 2024Article
- Gamma camera imaging characteristics ofEJNMMI physics · 2024Article
- Deep learning-based attenuation correction method inRadiological physics and technology · 2024Article
- Activity quantification and dosimetry in radiopharmaceutical therapy with reference toFrontiers in nuclear medicine · 2024Review
- Study on the knowledge, attitude and practice of single photon emission computed tomography among oncology healthcare professionals.Frontiers in public health · 2024Article
- QuantitativeEJNMMI physics · 2023Article
- A Review on the Use of Imaging Biomarkers in Oncology Clinical Trials: Quality Assurance Strategies for Technical Validation.Tomography (Ann Arbor, Mich.) · 2023Review
- Performance study of a 360° CZT camera for monitoringEJNMMI physics · 2023Article
- Feasibility of using counts-per-volume approach with a new SPECT phantom to optimize the relationship between administered dose and acquisition time.Radiological physics and technology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Absolute quantification of radiotracer distribution using SPECT/CT imaging is of great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many factors. Using phantom measurements, this multi-vendor and multi-center study evaluates the quantitative accuracy and inter-system variability of various SPECT/CT systems as well as the effect of patient size, processing software and reconstruction algorithms on recovery coefficients (RC).
methodsFive SPECT/CT systems were included: Discovery™ NM/CT 670 Pro (GE Healthcare), Precedence™ 6 (Philips Healthcare), Symbia Intevo™, and Symbia™ T16 (twice) (Siemens Healthineers). Three phantoms were used based on the NEMA IEC body phantom without lung insert simulating body mass indexes (BMI) of 25, 28, and 47 kg/m
resultsRC decreased with decreasing sphere diameter for each system. Inter-system variability (MAD) was 16 and 17% for RC
conclusionAbsolute SPECT quantification in a multi-center and multi-vendor setting is feasible, especially when reconstruction protocols are standardized, paving the way for a standard for absolute quantitative SPECT.
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