ArticleThe American journal of clinical nutrition2020
Race affects the association of obesity measures with insulin sensitivity.
Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Rethinking Biva in obesity: systematic vector displacement across the adiposity spectrum.European journal of clinical nutrition · 2026Article
- Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- Genetic Risk Phenotypes for Type 2 Diabetes Differ with Ancestry in US Adults with Diabetes and Overweight/Obesity.Archives of medical research · 2025Article
- Predictability of genetic risk score for insulin resistance is influenced by both BMI and race.Obesity (Silver Spring, Md.) · 2025Article
- Pathophysiological hallmarks in type 2 diabetes heterogeneity (review).Diabetology international · 2025Review
- Association between the triglyceride-glucose index and hyperuricemia: potential role of obesity in patients with Type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Diet and Survival in Black Women With Epithelial Ovarian Cancer.JAMA network open · 2024Article
- Article
- Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults.Diabetes care · 2023Article
- Associations of renal sinus fat with blood pressure and ectopic fat in a diverse cohort of adults.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Associations of atrial natriuretic peptide with measures of insulin and adipose depots.Physiological reports · 2023Article
- Obesity Pillars Roundtable: Body mass index and body composition in Black and Female individuals. Race-relevant or racist? Sex-relevant or sexist?Obesity pillars · 2022Article
- Association between long-term air pollution exposure and insulin resistance independent of abdominal adiposity in Korean adults.Scientific reports · 2022Article
- Relationship between obesity indicators and hypertension-diabetes comorbidity among adults: a population study from Central China.BMJ open · 2022Article
- Insulin Resistance and Cardiometabolic Risk Profile Among Nondiabetic American Young Adults: Insights From NHANES.The Journal of clinical endocrinology and metabolism · 2022Article
- Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men.Obesity science & practice · 2021Article
- Genetic risk score prediction of leg fat and insulin sensitivity differs by race/ethnicity in early pubertal children.Pediatric obesity · 2021Article
- Obesity and cancer death in white and black adults: A prospective cohort study.Obesity (Silver Spring, Md.) · 2021Article
- The Triple Health Threat of Diabetes, Obesity, and Cancer-Epidemiology, Disparities, Mechanisms, and Interventions.Obesity (Silver Spring, Md.) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRace differences in body composition and fat distribution may in part explain the differences in insulin sensitivity and the disproportionate burden of type 2 diabetes in African Americans.
objectiveTo determine if differences in body composition and fat distribution explain race differences in insulin sensitivity and identify obesity measures that were independently associated with insulin sensitivity.
methodsParticipants were 113 lean, overweight, and obese African-American and Caucasian-American adults without diabetes. Skeletal muscle insulin sensitivity was determined using a hyperinsulinemic-euglycemic clamp (SIClamp, insulin rate:120 mU/m2/min). Subcutaneous abdominal adipose tissue (SAAT), intra-abdominal adipose tissue (IAAT), and liver fat were measured by MRI; leg fat, total fat, and lean mass were measured by DXA.
resultsRace-by-adiposity interactions were significant in cross-sectional analyses utilizing multiple linear regression models for SIClamp (P < 0.05); higher BMI, fat mass, SAAT, leg fat, and liver fat were associated with lower SIClamp in Caucasian Americans but not African Americans. Race-by-IAAT interaction was not significant (P = 0.65). A central fat distribution (SAAT adjusted for leg fat) was associated with lower SIClamp in African Americans (β = -0.45, SE = 0.11, P < 0.001) but not Caucasian Americans (β = -0.42, SE = 0.30, P = 0.17). A peripheral fat distribution (leg fat adjusted for IAAT/SAAT) was associated with a higher SIClamp in African Americans (β = 0.11, SE = 0.05, P = 0.02) but lower SIClamp in Caucasian Americans (β = -0.28, SE = 0.14, P = 0.049). Lean mass was inversely associated with SIClamp in African Americans (β = -0.05, SE = 0.03, P = 0.04) but not Caucasian Americans (β = 0.08, SE = 0.05, P = 0.10) in the model for leg fat.
conclusionsMeasures of overall adiposity were more strongly associated with SIClamp in Caucasian Americans, whereas body fat distribution and lean mass showed stronger correlations with SIClamp in African Americans. Insulin sensitivity may have a genetic basis in African Americans that is reflected in the pattern of body fat distribution. These findings suggest a race-specific pathophysiology of insulin resistance, which has implications for the prevention of diabetes and related cardiometabolic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.