ArticleNeurobiology of stress2020
Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease.
Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Advancing Our Understanding of Depression-From Molecular Mechanisms to Novel Therapeutic Frontiers.International journal of molecular sciences · 2026Article
- Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.International journal of molecular sciences · 2026Article
- Structure-activity relationships of steroid and sterol neuromodulators on inflammatory markers in a murine microglial cell line.The Journal of steroid biochemistry and molecular biology · 2026Article
- Plasma Allopregnanolone and Sex Hormone Responses to Stress Induction: Contributors to the Formation of Intrusive Memories.Neuropsychobiology · 2026Article
- DASS-21 Stress, but Not Anxiety or Depression, Is Associated with Premenstrual Stress.Journal of clinical medicine · 2025Article
- Suicidality Risks Associated with Finasteride, a 5-Alpha Reductase Inhibitor: An Evaluation of Real-World Data from the FDA Adverse Event Reports.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Allopregnanolone Regulation of Phasic Dopamine Release and Motivated Behavior.ACS chemical neuroscience · 2025Article
- Sex and sobriety: Human brain structure and function in AUD abstinence.Alcohol (Fayetteville, N.Y.) · 2024Review
- Neurosteroid [3α,5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity.Life (Basel, Switzerland) · 2024Article
- Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats.Psychopharmacology · 2024Article
- Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders.Life (Basel, Switzerland) · 2024Review
- Local effect of allopregnanolone in rat ovarian steroidogenesis, follicular and corpora lutea development.Scientific reports · 2024Article
- Neurosteroids: mechanistic considerations and clinical prospects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Deleterious Interaction between the Neurosteroid (3α,5α)3-Hydroxypregnan-20-One (3α,5α-THP) and the Mu-Opioid System Activation during Forced Swim Stress in Rats.Biomolecules · 2023Article
- Article
- Research Trends and Hot Spots of Allopregnanolone Research in the Last 20 Years: A Bibliometric Analysis.Drug design, development and therapy · 2023Review
- Allopregnanolone pleiotropic action in neurons and astrocytes: calcium signaling as a unifying mechanism.Frontiers in endocrinology · 2023Article
- The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies.Biomolecules · 2022Review
- Neurosteroids and early-life programming: An updated perspective.Current opinion in endocrine and metabolic research · 2022Article
- Allopregnanolone in Postpartum Depression.Frontiers in global women's health · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
For several years, research from around the world has suggested that the neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone) may have therapeutic potential for treatment of various stress-related diseases including post-traumatic stress disorder (PTSD), depression, alcohol use disorders (AUDs), as well as neurological and psychiatric conditions that are worsened in the presence of stress, such as multiple sclerosis, schizophrenia, and seizure disorders. In this review, we make the argument that the pleiotropic actions of allopregnanolone account for its ability to promote recovery in such a wide variety of illnesses. Likewise, the allopregnanolone precursors, pregnenolone and progesterone, share many actions of allopregnanolone. Of course, pregnenolone and progesterone lack direct effects on GABA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.