Evidence map›Paper›PMID 31879567›Full record

ArticleTranslational vision science & technology2019

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by

Krunoslav T Stingl, Laura Kuehlewein, Nicole Weisschuh, Saskia Biskup, Frans P M Cremers, M Imran Khan, Carina Kelbsch, Tobias Peters, Marius Ueffing, Barbara Wilhelm and 2 more

Open access · goldAbstract read
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. ISCEV and IPS guideline for the full-field stimulus test (FST).Documenta ophthalmologica. Advances in ophthalmology · 2024
    Guideline
  2. Review
  3. Article
  4. The role of full-field stimulus threshold in evaluating Bietti crystalline dystrophy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Observational
  5. Novel Genotype-Phenotype Correlations inOphthalmology science · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. How lesions at different locations along the visual pathway influence pupillary reactions to chromatic stimuli.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Krunoslav T StinglCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Laura KuehleweinCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Nicole WeisschuhCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Saskia BiskupPraxis für Humangenetik Tübingen, Tübingen, Germany.
Frans P M CremersDepartment of Human Genetics, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
M Imran KhanDepartment of Human Genetics, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Carina KelbschCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Tobias PetersCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Marius UeffingCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Barbara WilhelmCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Eberhart ZrennerCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
Katarina StinglCenter for Ophthalmology, University of Tübingen, Tübingen, Germany.
University of Tübingen · DEPraxis für Humangenetik Tübingen · DERadboud University Medical Center · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMutations in the

methodsTen patients (five females, five males; age 22-56 years) with EORD caused by

resultsBCVA was quantifiable in six patients and ranged from light perception to 20/50. The visual field was measurable only in three patients who had the shortest disease duration. Full-field and multifocal electroretinography were not measurable in any patient. FST to blue and red light were measurable in all patients except the one with the longest disease duration; the thresholds ranged from -16.7 to 1.5 dB for red light and from -40.2 to 2.5 dB for blue light (0 dB = 0.01 cd.s/m

conclusionsFST features a valid clinical marker in late-stage early-onset retinitis pigmentosa caused by TRANSLATIONAL RELEVANCE: The functional measurements presented in this study present a valid clinical progression marker in late-stage early onset retinitis pigmentosa caused by biallelic

Indexed as

CRB1 mutationfunctional markerretinitis pigmentosa

Identifiers

PMID31879567
PMCPMC6927735
OpenAlexW2996664690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.