ReviewThe Japanese dental science review2020
Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands.
Review in The Japanese dental science review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Tooth Loss-Associated Mechanisms That Negatively Affect Cognitive Function: A Systematic Review of Animal Experiments Based on Occlusal Support Loss and Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Changes in salivary brain-derived neurotrophic factor following a standardized eating task in community-dwelling older adults: a cross-sectional study.Odontology · 2026Article
- Quantitative Analysis of Spontaneous Tongue Muscle Reinnervation after Long Nerve Resection for Hypoglossal Nerve Injury in Rats.Journal of musculoskeletal & neuronal interactions · 2026Article
- Association between masticatory function and cognitive ability in mild cognitive impairment.BMC geriatrics · 2026Article
- Effect of a digital-based integrated exercise and sleep intervention for older adults with depression: study protocol for a stepped-wedge cluster randomized controlled trial.BMC geriatrics · 2026Article
- Advances in research on dental occlusion and brain function: neuroimaging correlates and molecular mechanisms.Frontiers in neurology · 2026Review
- Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research.BMC oral health · 2025Article
- Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression.World journal of psychiatry · 2024Article
- Proteins from shrews' venom glands play a role in gland functioning and venom production.Zoological letters · 2024Article
- Neurotoxic stimulation alters prosaposin levels in the salivary systems of rats.Cell and tissue research · 2024Article
- Association between salivary mature brain-derived neurotrophic factor and psychological distress in healthcare workers.Brain and behavior · 2023Article
- Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence.Journal of eating disorders · 2022Article
- Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles.Bioactive materials · 2022Article
- Brain-derived Neurotropic factor (BDNF) mediates the protective effect of Cucurbita pepo L. on salivary glands of rats exposed to chronic stress evident by structural, biochemical and molecular study.Journal of applied oral science : revista FOB · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chewing is one of the most important orofacial functions. During this process, food is reduced in size, while saliva moistens the food and binds it into a bolus that can be easily swallowed. Characteristics of the oral system, including the number of teeth, bite force, and salivary flow, influence the masticatory process. In addition, salivary glands produce several cell growth factors and play an important role in human health. The nerve growth factor (NGF) family consists of NGF, brain-derived neurotrophic factor (BDNF), and neurotrophins-3 to 7. BDNF is a well-studied neurotrophin involved in the neurogenesis, differentiation, and maintenance of select peripheral and central neuronal cell populations during development and adulthood. However, there has been no detailed description of the expression of neurotrophins other than NGF in the salivary gland. We previously studied the effect of immobilization stress + chewing on BDNF secretion and its receptor, tyrosine receptor kinase B, in rat submandibular glands and found increased BDNF expression in duct cells under these conditions. In this review, we describe recent advances in understanding the role of stress and chewing-related BDNF in the saliva and salivary glands.
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