Evidence map›Paper›PMID 31879352›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Uncovering the functional residues of

Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe and 2 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Metabolite control of enzyme activity links stress to biosynthetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Jin-Zheng WangDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Yongxing LeiChinese Academy of Sciences (CAS) Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China.
Yanmei XiaoDepartment of Plant Biology, University of California, Davis, CA 95616.
Xiang HeDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Jiubo LiangDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Jishan JiangDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Shangzhi DongChinese Academy of Sciences (CAS) Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China.
Haiyan KeDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521.
Patricia LeonDepartamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, 62210 Cuernavaca, México.
Philipp ZerbeDepartment of Plant Biology, University of California, Davis, CA 95616.
Youli XiaoChinese Academy of Sciences (CAS) Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, 200032 Shanghai, China; ylxiao@sibs.ac.cn kdehesh@ucr.edu.
Katayoon DeheshDepartment of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521; ylxiao@sibs.ac.cn kdehesh@ucr.edu.
University of California, Riverside · USCenter for Excellence in Molecular Plant Sciences · CNChinese Academy of Sciences · CNUniversidad Nacional Autónoma de México · MXUniversity of California, Davis · US

Funding

Defining the Retrograde Plastid-to-Nucleus Stress Signaling PathwayR01GM107311 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI DEHESH, KATAYOON · 2013 to 2021
$2.5M
NIGMS NIH HHS R01 GM107311
6 · The paper itself

Abstract

The methylerythritol phosphate (MEP) pathway is responsible for producing isoprenoids, metabolites with essential functions in the bacterial kingdom and plastid-bearing organisms including plants and Apicomplexa. Additionally, the MEP-pathway intermediate methylerythritol cyclodiphosphate (MEcPP) serves as a plastid-to-nucleus retrograde signal. A suppressor screen of the high MEcPP accumulating mutant plant (

Indexed as

Amino Acid SubstitutionArabidopsisArabidopsis ProteinsBiosynthetic PathwaysCell NucleusEnzymesErythritolLigandsMolecular Docking SimulationOxidoreductasesPlants, Genetically ModifiedPlastidsTerpenesArabidopsis ProteinsAT5G60600 protein, ArabidopsisEnzymesErythritolhydroxymethylbutenyl 4-diphosphate synthaseLigandsmethyl-D-erythritol 2,4-cyclodiphosphateOxidoreductasesTerpenesHDS enzymeMEcPPMEP pathwayplastidretrograde signaling

Identifiers

PMID31879352
PMCPMC6955319
OpenAlexW2997804170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.