ArticleProceedings of the National Academy of Sciences of the United States of America2020
The frequency of cortical microstimulation shapes artificial touch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.Neurology · 2022Trial
- Advances in neuroprostheses: interfaces, materials, and applications.Nano convergence · 2026Review
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Linking spatially distributed neuronal activation overlap to the limits of perceptual discrimination in rodent primary somatosensory cortex.Frontiers in computational neuroscience · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Visual context affects the perceived timing of tactile sensations elicited through intracortical microstimulation: a case study of two participants.Journal of neurophysiology · 2025Article
- Disentangling indirect versus direct effects of somatosensory cortex microstimulation on neurons in primary motor and ventral premotor cortex.Journal of neural engineering · 2025Article
- Article
- Injecting information in the cortical reach-to-grasp network is effective in ventral but not dorsal nodes.Cell reports · 2025Article
- Conveying tactile object characteristics through customized intracortical microstimulation of the human somatosensory cortex.Nature communications · 2025Article
- Clinical Applications and Future Translation of Somatosensory Neuroprostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Integrated Microprism and Microelectrode Array for Simultaneous Electrophysiology and Two-Photon Imaging across All Cortical Layers.Advanced healthcare materials · 2024Article
- Visual context affects the perceived timing of tactile sensations elicited through intra-cortical microstimulation.bioRxiv : the preprint server for biology · 2024Article
- Article
- Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation.iScience · 2023Article
- Neural Plasticity in Sensorimotor Brain-Machine Interfaces.Annual review of biomedical engineering · 2023Review
- Restoration of sensory information via bionic hands.Nature biomedical engineering · 2023Review
- Review
- Characterizing the short-latency evoked response to intracortical microstimulation across a multi-electrode array.Journal of neural engineering · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Intracortical microstimulation (ICMS) of the somatosensory cortex evokes vivid tactile sensations and can be used to convey sensory feedback from brain-controlled bionic hands. Changes in ICMS frequency lead to changes in the resulting sensation, but the discriminability of frequency has only been investigated over a narrow range of low frequencies. Furthermore, the sensory correlates of changes in ICMS frequency remain poorly understood. Specifically, it remains to be elucidated whether changes in frequency only modulate sensation magnitude-as do changes in amplitude-or whether they also modulate the quality of the sensation. To fill these gaps, we trained monkeys to discriminate the frequency of ICMS pulse trains over a wide range of frequencies (from 10 to 400 Hz). ICMS amplitude also varied across stimuli to dissociate sensation magnitude from ICMS frequency and ensure that animals could not make frequency judgments based on magnitude. We found that animals could consistently discriminate ICMS frequency up to ∼200 Hz but that the sensory correlates of frequency were highly electrode dependent: On some electrodes, changes in frequency were perceptually distinguishable from changes in amplitude-seemingly giving rise to a change in sensory quality; on others, they were not. We discuss the implications of our findings for neural coding and for brain-controlled bionic hands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.