Evidence map›Paper›PMID 31879339›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

The functionally relevant site for paxilline inhibition of BK channels.

Yu Zhou, Xiao-Ming Xia, Christopher J Lingle

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Application of Modulators of CaInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Evaluation of fourChannels (Austin, Tex.) · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Progesterone activation of βNature communications · 2023
    Article
  12. TRPML3/BK complex promotes autophagy and bacterial clearance by providing a positive feedback regulation of mTOR via PI3P.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Migraine Treatment: Towards New Pharmacological Targets.International journal of molecular sciences · 2023
    Review
  14. Review
  15. KCurrent neuropharmacology · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yu ZhouDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110 zhouy@wustl.edu clingle@morpheus.wustl.edu.ORCID 0000-0002-1407-6140
Xiao-Ming XiaDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Christopher J LingleDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110 zhouy@wustl.edu clingle@morpheus.wustl.edu.ORCID 0000-0002-9916-3795
Washington University in St. Louis · US

Funding

SLO family potassium channels: function and physiologyR35GM118114 · NIGMS · WASHINGTON UNIVERSITY · PI LINGLE, CHRISTOPHER J · 2016 to 2025
$6.9M
NIGMS NIH HHS R35 GM118114
6 · The paper itself

Abstract

The tremorgenic fungal alkaloid paxilline (PAX) is a commonly used specific inhibitor of the large-conductance, voltage- and Ca

Indexed as

AnimalsBinding SitesIndolesIon Channel GatingLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMiceMolecular Docking SimulationProtein ConformationProtein DomainsIndolesKcnma1 protein, mouseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelspaxillineBK channelsCa2+- and voltage-gated K+ channelsK+ channelsmSlo1 channelspaxilline

Identifiers

PMID31879339
PMCPMC6969516
OpenAlexW2998572711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.