ArticleMolecular & cellular proteomics : MCP2020
Peptidomic Analysis of Urine from Youths with Early Type 1 Diabetes Reveals Novel Bioactivity of Uromodulin Peptides
Article in Molecular & cellular proteomics : MCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Degradation graphs reveal hidden proteolytic activity in peptidomes.PLoS computational biology · 2026Article
- Advances in uromodulin biology and potential clinical applications.Nature reviews. Nephrology · 2024Review
- Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data.Nature communications · 2024Article
- Investigating and Annotating the Human Peptidome Profile from Urine under Normal Physiological Conditions.Proteomes · 2024Article
- Recent progress in mass spectrometry-based urinary proteomics.Clinical proteomics · 2024Review
- Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Urinary endogenous peptides as biomarkers for prostate cancer.Oncology letters · 2023Article
- An endogenous amniotic fluid-derived 10-amino acid peptide improves lung development and hyperoxia injury.Translational pediatrics · 2023Article
- An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease.Nature communications · 2022Article
- Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS.Molecules (Basel, Switzerland) · 2021Article
- Combined proteomic/transcriptomic signature of recurrence post-liver transplantation for hepatocellular carcinoma beyond Milan.Clinical proteomics · 2021Article
- Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases.International journal of molecular sciences · 2021Review
- The tissue proteome in the multi-omic landscape of kidney disease.Nature reviews. Nephrology · 2021Review
- Combining Field-Enabled Capillary Vibrating Sharp-Edge Spray Ionization with Microflow Liquid Chromatography and Mass Spectrometry to Enhance 'Omics Analyses.Journal of the American Society for Mass Spectrometry · 2021Article
- Peptimetric: Quantifying and Visualizing Differences in Peptidomic Data.Frontiers in bioinformatics · 2021Article
- Inhibition of BRD4 Reduces Neutrophil Activation and Adhesion to the Vascular Endothelium Following Ischemia Reperfusion Injury.International journal of molecular sciences · 2020Article
- Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes.PloS one · 2020Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
Chronic hyperglycemia is known to disrupt the proteolytic milieu, initiating compensatory and maladaptive pathways in the diabetic kidney. Such changes in intrarenal proteolysis are captured by the urinary peptidome. To elucidate the early kidney response to chronic hyperglycemia, we conducted a peptidomic investigation into urines from otherwise healthy youths with type 1 diabetes and their non-diabetic peers using unbiased and targeted mass spectrometry-based techniques. This cross-sectional study included two separate cohorts for the discovery (
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Registered trials
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