Evidence map›Paper›PMID 31878936›Full record

ReviewReproductive biology and endocrinology : RB&E2019

Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis.

Saradha Baskaran, Ashok Agarwal, Manesh Kumar Panner Selvam, Renata Finelli, Kathy Amy Robert, Concetta Iovine, Peter Natesan Pushparaj, Luna Samanta, Avi Harlev, Ralf Henkel

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evaluation ofJournal of the Turkish German Gynecological Association · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Pathogenesis of Autoimmune Male Infertility: Juxtacrine, Paracrine, and Endocrine Dysregulation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
  19. Article
  20. Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 5 countries.

Saradha BaskaranAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-4499-8680
Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA. agarwaa@ccf.org.ORCID https://orcid.org/0000-0003-0585-1026
Manesh Kumar Panner SelvamAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-9120-2278
Renata FinelliAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-5926-6407
Kathy Amy RobertAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-9448-6341
Concetta IovineAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-9636-5842
Peter Natesan PushparajCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0001-7574-1880
Luna SamantaAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0002-2969-0071
Avi HarlevDepartment of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID https://orcid.org/0000-0001-7335-9258
Ralf HenkelAmerican Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, OH, 44195, USA.ORCID https://orcid.org/0000-0003-1128-2982
Cleveland Clinic · USBen-Gurion University of the Negev · ILKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis article describes the research trends in sperm DNA fragmentation (SDF) over the past 20 years (1999-2018) using a scientometric approach.

methodsA stepwise approach was adopted to retrieve scientometric data (articles per year, authors, affiliations, journals, countries) from Scopus and analyze the publication pattern of SDF with reference to key areas of research in the field of Andrology.

resultsA total of 2121 articles were retrieved related to SDF. Our data revealed an increasing research trend in SDF (n = 33 to n = 173) over the past 20 years (R

conclusionsOur analysis revealed an increasing trend in SDF publications predominantly investigating lifestyle, asthenozoospermia and varicocele conditions with TUNEL being the most widely used technique. A substantial increase in research is warranted to establish SDF as prognostic/diagnostic parameter to evaluate clinical scenarios and ART outcomes.

Indexed as

DNA FragmentationAsthenozoospermiaBiomedical ResearchDNA DamageHumansInfertility, MaleIn Situ Nick-End LabelingMaleNational Institutes of Health (U.S.)PublishingReproductive Techniques, AssistedSpermatozoaUnited StatesVaricoceleDiagnosisDNA fragmentationInfertility, malePrognosisPublicationsScientometric analysis

Identifiers

PMID31878936
PMCPMC6931248
OpenAlexW2998333949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.