ArticleBMC veterinary research2019
Comparative metabolome analysis of serum changes in sheep under overgrazing or light grazing conditions.
Article in BMC veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Awassi Ancestry-Associated Serum Metabolomic Signatures Reveal Immune-Metabolic Features Related to Health Robustness in Dairy Sheep.Veterinary sciences · 2026Article
- The Effect ofBiology · 2026Article
- Rumenomics: evaluation of rumen metabolites from healthy sheep identifies differentially produced metabolites across sex, age, and weight.Animal microbiome · 2026Article
- Candidate blood biomarkers linked with feed intake efficiency and weight gain in sheep.Scientific reports · 2026Article
- Housed feeding improves rumen health by influencing the composition of the microbiota in Honghe cattle.Frontiers in veterinary science · 2025Article
- Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages.Scientific reports · 2024Article
- Metabonomics study on the hepatoprotective effect mechanism of polysaccharides from different processed products of Angelica sinensis on layer chickens based on UPLC-Q/TOF-MS/MS, multivariate statistical analysis and conjoint analysis.Biomedical chromatography : BMC · 2022Article
- Plasma metabolomic profiles as affected by diet and stress in Spanish goats.Scientific reports · 2021Article
- Methyl-Donor Micronutrient for Gestating Sows: Effects on Gut Microbiota and Metabolome in Offspring Piglets.Frontiers in nutrition · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundOvergrazing is a primary contributor to severe reduction in forage quality and production in Inner Mongolia, leading to extensive ecosystem degradation, sheep health impairment and growth performance reduction. Further studies to identify serum biomarkers that reflect changes in sheep health and nutritional status following overgrazing would be beneficial. We hereby hypothesize that reduced sheep growth performance under overgrazing conditions would be associated with metabolic and immune response alterations. This study used an untargeted metabolomics analysis by conducting ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) of sheep serum under overgrazing and light grazing conditions to identify metabolic disruptions in response to overgrazing.
resultsThe sheep body weight gains as well as serum biochemical variables associated with immune responses and nutritional metabolism (immunoglobulin G, albumin, glucose, and nonesterified fatty acids) were significantly decreased with overgrazing compared with light grazing condition. In contrast, other serum parameters such as alanine and aspartate aminotransferase, alkaline phosphatase, total bilirubin, blood urea nitrogen, and interleukin-8 were markedly higher in the overgrazing group. Principal component analysis discriminated the metabolomes of the light grazing from the overgrazing group. Multivariate and univariate analyses revealed changes in the serum concentrations of 15 metabolites (9 metabolites exhibited a marked increase, whereas 6 metabolites showed a significant decrease) in the overgrazing group. Major changes of fatty acid oxidation, bile acid biosynthesis, and purine and protein metabolism were observed.
conclusionsThese findings offer metabolic evidence for putative biomarkers for overgrazing-induced changes in serum metabolism. Target-identification of these particular metabolites may potentially increase our knowledge of the molecular mechanisms of altered immune responses, nutritional metabolism, and reduced sheep growth performance under overgrazing conditions.
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