Evidence map›Paper›PMID 31878917›Full record

ArticleBMC musculoskeletal disorders2019

Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control study within the Wakayama spine study.

Yuyu Ishimoto, Cyrus Cooper, Georgia Ntani, Hiroshi Yamada, Hiroshi Hashizume, Keiji Nagata, Shigeyuki Muraki, Sakae Tanaka, Munehito Yoshida, Noriko Yoshimura and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Degenerative Spondylolisthesis: A Narrative Review.Acta bio-medica : Atenei Parmensis · 2022
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yuyu IshimotoMRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, Hampshire, UK. yuyu.ishimoto@hotmail.co.jp.
Cyrus CooperMRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, Hampshire, UK.
Georgia NtaniMRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, Hampshire, UK.
Hiroshi YamadaOrthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan.
Hiroshi HashizumeOrthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan.
Keiji NagataOrthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan.
Shigeyuki MurakiDepartment of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Sakae TanakaDepartment of Orthopedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Munehito YoshidaOrthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan.
Noriko YoshimuraDepartment of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
Karen Walker-BoneMRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, Hampshire, UK.
Southampton General Hospital · GBWakayama Medical University · JPThe University of Tokyo · JP

Funding

Grant-in-Aid for the Promotion of joint International Research from Japan Society for the Promotion of Science. 15KK0316Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585823Medical Research Council MC_U147585824Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/5
6 · The paper itself

Abstract

backgroundTo explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS).

methodsThe WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures.

resultsIn total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥4 h/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged < 75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking.

conclusionsA history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

Indexed as

Lumbar VertebraeAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedOccupational ExposureSpondylolisthesisAgricultural /drivingOccupationSpondylolisthesis

Identifiers

PMID31878917
PMCPMC6933670
OpenAlexW2997587161

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.