Evidence map›Paper›PMID 31878769›Full record

ArticleThe Korean journal of internal medicine2020

The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers.

Seung Soo Yoo, Hyo-Gyoung Kang, Jin Eun Choi, Mi Jeong Hong, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Seung Soo YooDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Hyo-Gyoung KangDepartment of Biochemistry and Cell Biology, Kyungpook National University, Daegu, Korea.
Jin Eun ChoiDepartment of Biochemistry and Cell Biology, Kyungpook National University, Daegu, Korea.
Mi Jeong HongDepartment of Biochemistry and Cell Biology, Kyungpook National University, Daegu, Korea.
Sook Kyung DoDepartment of Biochemistry and Cell Biology, Kyungpook National University, Daegu, Korea.
Jang Hyuck LeeDepartment of Biochemistry and Cell Biology, Kyungpook National University, Daegu, Korea.
Won Kee LeeBiostatistics, Medical Research Collaboration Center, Kyungpook National University, Daegu, Korea.
Shin Yup LeeDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Jaehee LeeDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Seung Ick ChaDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Chang Ho KimDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Eung Bae LeeDepartment of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.
Jae Yong ParkDepartment of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
Kyungpook National University · KRKyungpook National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsGenome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers.

methodsThis study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay.

resultsTwo polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p = 0.02). The rs9387478 polymorphism also reduced lung cancer risk in male smokers (in a codominant model: odds ratio, 0.85; 95% confidence interval, 0.73 to 0.997; p = 0.046). In a stratified analysis, the association between these polymorphisms and the risk of lung cancer was predominant in lighter smokers and for cases of adenocarcinoma.

conclusionThese results suggest that a subset of polymorphisms known to be associated with the risk of lung cancer in female never smokers is also associated with the risk of lung cancer in male smokers.

Indexed as

Lung NeoplasmsSmokersCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMalePolymorphism, GeneticPolymorphism, Single NucleotideRisk FactorsSmokingLung neoplasmsNon-smokersPolymorphismRiskSmokers

Identifiers

PMID31878769
PMCPMC7373985
OpenAlexW2997659513

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.