ArticlePathogens (Basel, Switzerland)2019
Human Microglia Respond to Malaria-Induced Extracellular Vesicles.
Article in Pathogens (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Activation of macrophages by extracellular vesicles derived fromInfection and immunity · 2025Article
- Host-Pathogen Cellular Communication: The Role of Dynamin, Clathrin, and Macropinocytosis in the Uptake of Giardia-Derived Extracellular Vesicles.ACS infectious diseases · 2025Article
- Review
- A Reproducible Protocol for the Isolation of Malaria-Derived Extracellular Vesicles by Differential Centrifugation.Methods and protocols · 2024Article
- Progress on the Regulation of the Host Immune Response by Parasite-Derived Exosomes.Pathogens (Basel, Switzerland) · 2024Review
- Quantifying microglial morphology: an insight into function.Clinical and experimental immunology · 2024Review
- Drug-induced stress mediatesMicrobiology spectrum · 2024Article
- Extracellular Vesicles in Malaria: Shedding Light on Pathogenic Depths.ACS infectious diseases · 2024Review
- Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes.Scientific reports · 2023Article
- Roles and Applications of Red Blood Cell-Derived Extracellular Vesicles in Health and Diseases.International journal of molecular sciences · 2022Review
- Protein Profiling of Malaria-Derived Extracellular Vesicles Reveals Distinct Subtypes.Membranes · 2022Article
- Reactive morphology of dividing microglia following kainic acid administration.Frontiers in neuroscience · 2022Article
- Validation of Effective Extracellular Vesicles Isolation Methods Adapted to Field Studies in Malaria Endemic Regions.Frontiers in cell and developmental biology · 2022Article
- Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2022Review
- Extracellular vesicles in malaria: an agglomeration of two decades of research.Malaria journal · 2021Review
- Factors influencing phagocytosis of malaria parasites: the story so far.Malaria journal · 2021Review
- The Potential Roles of Glial Cells in the Neuropathogenesis of Cerebral Malaria.Frontiers in cellular and infection microbiology · 2021Review
- Microglia and astrocyte responses to neuropathogenic protozoan parasites.Faculty reviews · 2021Review
- A Profound Membrane Reorganization Defines Susceptibility ofFrontiers in immunology · 2021Article
- Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia are the chief immune cells of the brain and have been reported to be activated in severe malaria. Their activation may drive towards neuroinflammation in cerebral malaria. Malaria-infected red blood cell derived-extracellular vesicles (MiREVs) are produced during the blood stage of malaria infection. They mediate intercellular communication and immune regulation, among other functions. During cerebral malaria, the breakdown of the blood-brain barrier can promote the migration of substances such as MiREVs from the periphery into the brain, targeting cells such as microglia. Microglia and extracellular vesicle interactions in different pathological conditions have been reported to induce neuroinflammation. Unlike in astrocytes, microglia-extracellular vesicle interaction has not yet been described in malaria infection. Therefore, in this study, we aimed to investigate the uptake of MiREVs by human microglia cells and their cytokine response. Human blood monocyte-derived microglia (MoMi) were generated from buffy coats of anonymous healthy donors using Ficoll-Paque density gradient centrifugation. The MiREVs were isolated from the
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