Evidence map›Paper›PMID 31878280›Full record

ArticleInternational journal of molecular sciences2019

Gene Copy Number and Post-Transductional Mechanisms Regulate TRAP1 Expression in Human Colorectal Carcinomas.

Michele Pietrafesa, Francesca Maddalena, Luciana Possidente, Valentina Condelli, Pietro Zoppoli, Valeria Li Bergolis, Maria Grazia Rodriquenz, Michele Aieta, Giulia Vita, Franca Esposito and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Michele PietrafesaLaboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.ORCID 0000-0003-2059-9156
Francesca MaddalenaLaboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Luciana PossidentePathology Unit, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Valentina CondelliLaboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Pietro ZoppoliLaboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.ORCID 0000-0002-7860-9655
Valeria Li BergolisMedical Oncology Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71100 Foggia, Italy.
Maria Grazia RodriquenzMedical Oncology Unit, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Michele AietaMedical Oncology Unit, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Giulia VitaPathology Unit, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.
Franca EspositoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-9340-6875
Matteo LandriscinaLaboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Via Padre Pio 1, 85028 Rionero in Vulture, Italy.ORCID 0000-0003-0591-9799
Centro di Riferimento Oncologico della Basilicata · ITUniversity of Foggia · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a heat shock protein 90 (HSP90) molecular chaperone overexpressed in 60-70% human colorectal carcinomas (CRCs) and the co-upregulation of TRAP1 and associated 6-related proteins identifies metastatic CRCs with poor prognosis. Since the molecular mechanisms responsible for TRAP1 regulation are still unknown, the significance of

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsFemaleGene DosageGene Expression Regulation, NeoplasticHSP90 Heat-Shock ProteinsHumansMaleMiddle AgedProteomicsHSP90 Heat-Shock ProteinsTRAP1 protein, humancolorectal carcinomacopy number variationGSNORS-nitrosylationTRAP1

Identifiers

PMID31878280
PMCPMC6981705
OpenAlexW2998203655

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.