Evidence map›Paper›PMID 31878197›Full record

ReviewInternational journal of molecular sciences2019

Recent Developments of Electrochemical and Optical Biosensors for Antibody Detection.

Wei Xu, Daniel Wang, Derek Li, Chung Chiun Liu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
  7. Molecular Diagnosis and Cancer Prognosis-A Concise Review.Diagnostics (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wei XuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Daniel WangDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Derek LiSolon High School, Solon, OH 44106, USA.
Chung Chiun LiuDepartment of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Case Western Reserve University · USHunter Defense Technologies (United States) · US

Funding

Wallace R. Persons Research Fund of Case Alumni Association RES426864
6 · The paper itself

Abstract

Detection of biomarkers has raised much interest recently due to the need for disease diagnosis and personalized medicine in future point-of-care systems. Among various biomarkers, antibodies are an important type of detection target due to their potential for indicating disease progression stage and the efficiency of therapeutic antibody drug treatment. In this review, electrochemical and optical detection of antibodies are discussed. Specifically, creating a non-label and reagent-free sensing platform and construction of an anti-fouling electrochemical surface for electrochemical detection are suggested. For optical transduction, a rapid and programmable platform for antibody detection using a DNA-based beacon is suggested as well as the use of bioluminescence resonance energy transfer (BRET) switch for low cost antibody detection. These sensing strategies have demonstrated their potential for resolving current challenges in antibody detection such as high selectivity, low operation cost, simple detection procedures, rapid detection, and low-fouling detection. This review provides a general update for recent developments in antibody detection strategies and potential solutions for future clinical point-of-care systems.

Indexed as

AntibodiesBiosensing TechniquesElectrochemical TechniquesHumansLuminescent MeasurementsAntibodiesantibody detectionbiosensorselectrochemical detectionoptical detection

Identifiers

PMID31878197
PMCPMC6981776
OpenAlexW2996844466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.