Evidence map›Paper›PMID 31878161›Full record

ArticleVaccines2019

Systems Vaccinology for a Live Attenuated Tularemia Vaccine Reveals Unique Transcriptional Signatures That Predict Humoral and Cellular Immune Responses.

Muktha S Natrajan, Nadine Rouphael, Lilin Lai, Dmitri Kazmin, Travis L Jensen, David S Weiss, Chris Ibegbu, Marcelo B Sztein, William F Hooper, Heather Hill and 6 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. The immune response toFrontiers in microbiology · 2025
    Review
  3. Article
  4. Article
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  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Japanese Encephalitis Vaccines.Current treatment options in infectious diseases · 2020
    Review
  17. Current Challenges in Vaccinology.Frontiers in immunology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Muktha S NatrajanHope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA 30030, USA.
Nadine RouphaelHope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA 30030, USA.
Lilin LaiHope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA 30030, USA.
Dmitri KazminEmory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
Travis L JensenThe EMMES Corporation, Rockville, MD 20850, USA.
David S WeissHope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA 30030, USA.
Chris IbegbuEmory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
William F HooperThe EMMES Corporation, Rockville, MD 20850, USA.
Heather HillThe EMMES Corporation, Rockville, MD 20850, USA.
Evan J AndersonDepartments of Medicine and Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-1576-4420
Robert JohnsonBiomedical Advanced Research and Development Authority, ASPR, Department of Health and Human Services, Washington, DC 20201, USA.
Patrick SanzDivision of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
Bali PulendranEmory Vaccine Center, Emory University, Atlanta, GA 30322, USA.
Johannes B GollThe EMMES Corporation, Rockville, MD 20850, USA.
Mark J MulliganHope Clinic, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Decatur, GA 30030, USA.
Emory University · USEmmes (United States) · USBiomedical Advanced Research and Development Authority · USNational Institutes of Health · USUniversity of Maryland, Baltimore · US

Funding

Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2009 to 2018
$27.8M
ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)U01AI047996 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOEPFERT, PAUL A. · 2000 to 2006
$8.4M
MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITYR01AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2001 to 2024
$4.5M
Center for AIDS Research, Emory University P30 A1050409NIAID NIH HHS R01 AI048638NIAID NIH HHS U01 AI047996NIH HHS HHSN272200800005CNIH HHS HHSN272200800013CNIH HHS HHSN272201300018INIH HHS HHSN272201500002CNIH HHS HHSN27220800057C
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

comparative vaccinesimmune signalinglive attenuated vaccinestranscriptomicstularemia

Identifiers

PMID31878161
PMCPMC7158697
OpenAlexW2997518224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.