Evidence map›Paper›PMID 31878115›Full record

ArticleInternational journal of molecular sciences2019

The Influence of Quadruplex Structure in Proximity to P53 Target Sequences on the Transactivation Potential of P53 Alpha Isoforms.

Otília Porubiaková, Natália Bohálová, Alberto Inga, Natália Vadovičová, Jan Coufal, Miroslav Fojta, Václav Brázda

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  8. Amino Acid Composition in Various Types of Nucleic Acid-Binding Proteins.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Otília PorubiakováFaculty of Chemistry, Brno University of Technology, Purkyňova 118, 61200 Brno, Czech Republic.ORCID 0000-0001-9940-0941
Natália BohálováInstitute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic.
Alberto IngaLaboratory of Transcriptional Networks, Department CIBIO, University of Trento, via Sommarive 9, 38123 Trento, Italy.ORCID 0000-0002-8767-1637
Natália VadovičováInstitute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic.
Jan CoufalInstitute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic.
Miroslav FojtaInstitute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic.
Václav BrázdaFaculty of Chemistry, Brno University of Technology, Purkyňova 118, 61200 Brno, Czech Republic.ORCID 0000-0003-2837-4226
Czech Academy of Sciences · CZUniversity of Trento · IT

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/15 003/0000477Grantová Agentura České Republiky 18-15548S
6 · The paper itself

Abstract

p53 is one of the most studied tumor suppressor proteins that plays an important role in basic biological processes including cell cycle, DNA damage response, apoptosis, and senescence. The human

Indexed as

G-QuadruplexesApoptosis Regulatory ProteinsHumansPromoter Regions, GeneticProtein BindingProtein IsoformsProto-Oncogene ProteinsResponse ElementsTumor Suppressor Protein p53Apoptosis Regulatory ProteinsBBC3 protein, humanProtein IsoformsProto-Oncogene ProteinsTumor Suppressor Protein p53p53 proteinprotein-DNA interactiontransactivation potential

Identifiers

PMID31878115
PMCPMC6982142
OpenAlexW2996487863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.