ArticleBrain sciences2019
The Tolerability and Efficacy of 4 mA Transcranial Direct Current Stimulation on Leg Muscle Fatigability.
Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The influence of a single transcranial direct current stimulation session on physical fitness in healthy subjects: a systematic review.Experimental brain research · 2023Pooled it
- Acute effects of anodal transcranial direct current stimulation on maximal voluntary force, repeated maximal isometric contractions and corticospinal excitability in healthy young adults.European journal of applied physiology · 2026Trial
- Bifrontal transcranial direct current stimulation modulates fatigue in multiple sclerosis: a randomized sham-controlled study.Journal of neural transmission (Vienna, Austria : 1996) · 2020Trial
- Churning Better Transcranial Direct Current Stimulation Outcome with Accelerated Protocols: Understanding the Non-linear Dynamics through Metaplasticity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Research progress on transcranial direct current stimulation for improving muscle strength: a narrative review.Frontiers in neurology · 2025Review
- The Modulatory Effects of Transcranial Alternating Current Stimulation on Brain Oscillatory Patterns in the Beta Band in Healthy Older Adults.Brain sciences · 2024Article
- Individuals with psychosis receive less electric field strength during transcranial direct current stimulation compared to healthy controls.Schizophrenia (Heidelberg, Germany) · 2024Article
- The Effect of Transcranial Direct Current Stimulation on Lower-Limb Endurance Performance: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
- Optimized APPS-tDCS electrode position, size, and distance doubles the on-target stimulation magnitude in 3000 electric field models.Scientific reports · 2022Article
- Inter-Individual Variability in tDCS Effects: A Narrative Review on the Contribution of Stable, Variable, and Contextual Factors.Brain sciences · 2022Review
- High Estrogen Levels Cause Greater Leg Muscle Fatigability in Eumenorrheic Young Women after 4 mA Transcranial Direct Current Stimulation.Brain sciences · 2022Article
- On the Effects of Transcranial Direct Current Stimulation on Cerebral Glucose Uptake During Walking: A Report of Three Patients With Multiple Sclerosis.Frontiers in human neuroscience · 2022Article
- Alterations in Leg Muscle Glucose Uptake and Inter-Limb Asymmetry after a Single Session of tDCS in Four People with Multiple Sclerosis.Brain sciences · 2021Article
- Focality-Oriented Selection of Current Dose for Transcranial Direct Current Stimulation.Journal of personalized medicine · 2021Article
- Personal Protective Equipment Alters Leg Muscle Fatigability Independent of Transcranial Direct Current Stimulation: A Comparison with Pre-COVID-19 Pandemic Results.Brain sciences · 2021Article
- Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro.Scientific reports · 2021Article
- Individual Cerebral Blood Flow Responses to Transcranial Direct Current Stimulation at Various Intensities.Brain sciences · 2020Article
- Different Effects of Transcranial Direct Current Stimulation on Leg Muscle Glucose Uptake Asymmetry in Two Women with Multiple Sclerosis.Brain sciences · 2020Article
- Transcranial Direct Current Stimulation at 4 mA Induces Greater Leg Muscle Fatigability in Women Compared to Men.Brain sciences · 2020Article
- Cerebellar Transcranial Direct Current Stimulation in People with Parkinson's Disease: A Pilot Study.Brain sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) modulates cortical excitability and affects a variety of outcomes. tDCS at intensities ≤2 mA is well-tolerated, but the tolerability and efficacy of tDCS at intensities >2 mA merits systematic investigation. The study objective was to determine the tolerability and effects of 4 mA tDCS on leg muscle fatigability. Thirty-one young, healthy adults underwent two randomly ordered tDCS conditions (sham, 4 mA) applied before and during an isokinetic fatigue test of the knee extensors and flexors. Subjects reported the severity of the sensations felt from tDCS. Primary outcomes were sensation tolerability and the fatigue index of the knee extensors and flexors. A repeated-measures ANOVA determined statistical significance (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.