Evidence map›Paper›PMID 31877781›Full record

ArticleCells2019

Isoform-Specific Roles of ERK1 and ERK2 in Arteriogenesis.

Nicolas Ricard, Jiasheng Zhang, Zhen W Zhuang, Michael Simons

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Flavonoids with Anti-Angiogenesis Function in Cancer.Molecules (Basel, Switzerland) · 2024
    Review
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  7. Environmental and intrinsic modulations of venous differentiation.Cellular and molecular life sciences : CMLS · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. MAPKs Are Highly Abundant but Do Not Contribute to αInternational journal of molecular sciences · 2021
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicolas RicardDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511 USA.
Jiasheng ZhangDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511 USA.ORCID 0000-0002-4637-5655
Zhen W ZhuangDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511 USA.
Michael SimonsDepartment of Internal Medicine, Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT 06511 USA.ORCID 0000-0003-0348-7734
Yale University · US

Funding

Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8M
NHLBI NIH HHS P01 HL107205NIH HHS HL062289
6 · The paper itself

Abstract

Despite the clinical importance of arteriogenesis, this biological process is poorly understood. ERK1 and ERK2 are key components of a major intracellular signaling pathway activated by vascular endothelial growth (VEGF) and FGF2, growth factors critical to arteriogenesis. To investigate the specific role of each ERK isoform in arteriogenesis, we used mice with a global

Indexed as

AnimalsArteriesCell ProliferationCells, CulturedFemaleHumansHuman Umbilical Vein Endothelial CellsIsoenzymesMacrophagesMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3IsoenzymesMAPK1 protein, humanMapk1 protein, mouseMAPK3 protein, humanMapk3 protein, mouseMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Vascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseangiogenesis, arteriogenesis, ERK, VEGF, endothelial cells, inflammation, macrophages

Identifiers

PMID31877781
PMCPMC7017123
OpenAlexW2994849646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.