Evidence map›Paper›PMID 31877768›Full record

ArticleCancers2019

miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers.

Thomas Stefan Worst, Christopher Previti, Katja Nitschke, Nicolle Diessl, Julia Christina Gross, Lena Hoffmann, Lisa Frey, Vanessa Thomas, Christoph Kahlert, Karen Bieback and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Pooled it
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  11. Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Thomas Stefan WorstDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Christopher PrevitiOmics IT and Data Management Core Facility (ODCF), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Katja NitschkeDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Nicolle DiesslGenomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Julia Christina GrossDepartments of Haematology and Oncology and Developmental Biochemistry, University Medicine Göttingen, 37075 Göttingen, Germany.
Lena HoffmannDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Lisa FreyDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Vanessa ThomasDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Christoph KahlertDepartment of Gastrointestinal, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Karen BiebackInstitute of Transfusion Medicine and Immunology, FlowCore Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Adriana Torres CrignaInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Fabia FrickeDepartment of Applied Tumor Biology, Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Stefan PorubskyInstitute of Pathology, Medical Faculty Mannheim, Heidelberg Heidelberg, 68167 Mannheim, Germany.
Niklas WesthoffDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jost von HardenbergDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Philipp NuhnDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Philipp ErbenDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Maurice Stephan MichelDepartment of Urology and Urosurgery, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Michael BoutrosDivision of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Heidelberg University · DEGerman Cancer Research Center · DEUniversitätsmedizin Göttingen · DEUniversity Hospital Carl Gustav Carus · DE

Funding

German Society of Urology WoT1/FE-14
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are shed by many different cell types. Their nucleic acids content offers new opportunities for biomarker research in different solid tumors. The role of EV RNA in prostate cancer (PCa) is still largely unknown. EVs were isolated from different benign and malignant prostate cell lines and blood plasma from patients with PCa (

Indexed as

extracellular vesiclesmir-10a-5pmiR-29b-3pmiR-99b-5pmiRNAnext generation sequencingnon-coding RNAprostate cancerqRT-PCR

Identifiers

PMID31877768
PMCPMC7017198
OpenAlexW2994624533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.