Evidence map›Paper›PMID 31877502›Full record

ArticleOral oncology2020

Patient-reported financial toxicity and adverse medical consequences in head and neck cancer.

Whitney H Beeler, Emily L Bellile, Keith A Casper, Elizabeth Jaworski, Nicholas J Burger, Kelly M Malloy, Matthew E Spector, Andrew G Shuman, Andrew Rosko, Chaz L Stucken and 11 more

Open access · greenAbstract read
In one paragraph

Article in Oral oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Exploring the role of health-related quality of life measures in predictive modelling for oncology: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
  2. Measuring financial toxicity in head and neck cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Pooled it
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  12. Implementation Mapping to Identify Strategies to Increase Timely Postoperative Radiotherapy Initiation for Head/Neck Cancer.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
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  20. Severity of Financial Toxicity for Patients Receiving Palliative Radiation Therapy.The American journal of hospice & palliative care · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Whitney H BeelerDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Emily L BellileDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, United States.
Keith A CasperDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Elizabeth JaworskiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Nicholas J BurgerDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Kelly M MalloyDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Matthew E SpectorDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Andrew G ShumanDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States; Department of Otolaryngology, Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States.
Andrew RoskoDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Chaz L StuckenDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Steven B ChinnDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Aleksandar F DragovicDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Christina H ChapmanDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States; Department of Radiation Oncology, Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States.
Dawn OwenDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Shruti JollyDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Carol R BradfordDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Mark E P PrinceDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States; Department of Otolaryngology, Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States.
Francis P WordenDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.
Reshma JagsiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Michelle L MierzwaDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States.
Paul L SwiecickiDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, United States; Department of Internal Medicine, Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, United States. Electronic address: pswiecic@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Functional imaging-directed adaptive therapy of head and neck cancerR01CA184153 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAO, YUE · 2015 to 2019
$2.4M
NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA184153
6 · The paper itself

Abstract

objectivesFinancial toxicity (FT) is a significant barrier to high-quality cancer care, and patients with head and neck cancer (HNCA) are particularly vulnerable given their need for intensive support, daily radiotherapy (RT), and management of long-term physical, functional, and psychosocial morbidities following treatment. We aim to identify predictors of FT and adverse consequences in HNCA following RT. MATERIALS AND

methodsWe performed a prospective survey study of patients with HNCA seen in follow-up at an academic comprehensive cancer center (CCC) or Veterans Affairs hospital between 05/2016 and 06/2018. Surveys included validated patient-reported functional outcomes and the COST measure, a validated instrument for measuring FT.

resultsThe response rate was 86% (n = 63). Younger age and lower median household income by county were associated with lower COST scores (i.e., worse FT) on multivariable analysis (p = .045 and p = .016, respectively). Patients with worse FT were more likely to skip clinic visits (RR (95% CI) 2.13 (1.23-3.67), p = .007), be noncompliant with recommended supplements or medications (1.24 (1.03-1.48), p = .02), and require supportive infusions (1.10 (1.02-1.20), p = .02). At the CCC, patients with worse FT were more likely to require feeding tubes (1.62 (1.14-2.31), p = .007). Overall, 36% reported that costs were higher than expected, 48% were worried about paying for treatment, and 33% reported at least a moderate financial burden from treatment.

conclusionHNCA patients experience substantial FT from their diagnosis and/or therapy, with potential implications for medical compliance, QOL, and survivorship care.

Indexed as

Cost of IllnessHealth ExpendituresAdultAgedAged, 80 and overFemaleHead and Neck NeoplasmsHealth Services AccessibilityHumansInsurance, HealthMaleMiddle AgedPatient Reported Outcome MeasuresPublic Health SurveillanceQuality of LifeSelf ReportHead and neck neoplasmsHealth care costsHealth expendituresQuality of life

Identifiers

PMID31877502
PMCPMC7008081
OpenAlexW2997089336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.