ArticleEBioMedicine2020
Lipidomic profiling identifies signatures of metabolic risk.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01410318 (Early Detection and Progression of Subclinical Atherosclerosis and Its Relationship to Coronary Risk Factors), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection and Progression of Subclinical Atherosclerosis and Its Relationship to Coronary Risk Factors
Who cites it
47 citing papers in PubMed, 87 citations in OpenAlex.
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- Calibrated dietary patterns and cancer risk in the women's health initiative cohorts.American journal of epidemiology · 2026Observational
- Metabolic Mechanisms of Modified Lingguizhugan Decoction in Obesity and Lipid Metabolism Disorders: A Multi-Omics Approach.Obesity science & practice · 2026Article
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- Predictive Utility and Metabolomic Signatures of TG/HDL-C Ratio for Metabolic Syndrome Without Cardiovascular Disease and/or Diabetes in Qatari Adults.Metabolites · 2025Article
- Circulating metabolomic biomarkers of 5-year body weight and composition change in a biracial cohort of community-dwelling older adults.GeroScience · 2025Article
- Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women.Breast cancer research : BCR · 2025Article
- Establishment and Evaluation of a Risk Prediction Model for Abnormal Circadian Rhythm of Blood Pressure in Young Hypertensive Patients.International journal of general medicine · 2025Article
- Comparative Analysis of Plasma Lipids and Apolipoproteins in Children with Down Syndrome and Implications for Cardiovascular Risk.Archives of basic and applied medicine · 2024Article
- Serum isthmin-1 is a potential biomarker for metabolic dysfunction associated fatty liver disease in patients with metabolic syndrome and type 2 diabetes mellitus.BMJ open diabetes research & care · 2024Article
- Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery.iScience · 2024Article
- Polygenic scores for complex traits are associated with changes in concentration of circulating lipid species.PLoS biology · 2024Article
- Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches.Nature reviews. Endocrinology · 2024Review
- Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.Environmental health perspectives · 2024Article
- Lipidomic signatures in Colombian adults with metabolic syndrome.Journal of diabetes and metabolic disorders · 2024Article
- Circadian organization of lipid landscape is perturbed in type 2 diabetic patients.Cell reports. Medicine · 2023Article
- Metabolomic profiles of chronic distress are associated with cardiovascular disease risk and inflammation-related risk factors.Brain, behavior, and immunity · 2023Observational
- Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts.Nature communications · 2023Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 4 countries.
Funding
Abstract
backgroundMetabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors.
methodsWe measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors.
resultsThirty-nine lipids were associated with obesity and eight with dysglycemia in the FHS. Of 32 lipids that were available for replication for obesity and six for dyslipidemia, 28 (88%) replicated for obesity and five (83%) for dysglycemia. Four lipids were associated with longitudinal changes in body mass index and four were associated with changes in fasting blood glucose in the FHS.
conclusionsWe identified and replicated several novel lipid biomarkers of key metabolic traits. The lipid moieties identified in this study are involved in biological pathways of metabolic risk and can be explored for prognostic and therapeutic utility.
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