Evidence map›Paper›PMID 31877355›Full record

ReviewFree radical biology & medicine2020

Non-redox cycling mechanisms of oxidative stress induced by PM metals.

James M Samet, Hao Chen, Edward R Pennington, Philip A Bromberg

Open access · greenAbstract readReview
In one paragraph

Review in Free radical biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. The predictive value of multiple urinary metals in evaluating death risk in asthmatic individuals: a prospective cohort study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  6. Review
  7. Review
  8. PMToxicology and applied pharmacology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Oxidative stress in air pollution research.Free radical biology & medicine · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

James M SametEnvironmental Public Health Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Chapel Hill, NC, USA. Electronic address: Samet.James@epa.gov.
Hao ChenOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Edward R PenningtonOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Philip A BrombergCenter for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oak Ridge Associated Universities · USEnvironmental Protection Agency · USUniversity of North Carolina at Chapel Hill · US

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Metallic compounds contribute to the oxidative stress of ambient particulate matter (PM) exposure. The toxicity of redox inert ions of cadmium, mercury, lead and zinc, as well as redox-active ions of vanadium and chromium is underlain by dysregulation of mitochondrial function and loss of signaling quiescence. Central to the initiation of these effects is the interaction of metal ions with cysteinyl thiols on glutathione and key regulatory proteins, which leads to impaired mitochondrial electron transport and persistent pan-activation of signal transduction pathways. The mitochondrial and signaling effects are linked by the production of H

Indexed as

Hydrogen PeroxideOxidative StressGlutathioneMetalsOxidation-ReductionGlutathioneHydrogen PeroxideMetals

Identifiers

PMID31877355
PMCPMC7803379
OpenAlexW2998098744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.