ArticleJournal of cachexia, sarcopenia and muscle2020
Grip strength mediates the relationship between muscle mass and frailty.
Article in Journal of cachexia, sarcopenia and muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of the relationship between body composition including muscle, fat, bone, and body water and frailty in Asian residents.Nagoya journal of medical science · 2025Pooled it
- Pooled it
- Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies.Aging clinical and experimental research · 2022Pooled it
- Trial
- The relationship between pulmonary function, and hand grip strength among young adults: a cross-sectional study.European journal of applied physiology · 2026Article
- Cognitive Function Mediates the Association Between Type 2 Diabetes and Physical Performance Decline in Older Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- How health literacy and eHealth literacy influence quality of life in older adults with chronic diseases: a network and path analysis.Health and quality of life outcomes · 2026Article
- The association between sarcopenia and frailty in older adults: a moderated mediation model.BMC geriatrics · 2026Article
- Higher Grip Strength Is Associated With Reduced Risk of Incident Symptomatic Hand Osteoarthritis: Data From Two Cohort Studies.Journal of cachexia, sarcopenia and muscle · 2026Article
- Age-Related Structural-Functional Discrepancy in Muscle Indicators Among Rural Korean Older Women.Journal of aging research · 2026Article
- A home and community-based multicomponent physical activity intervention program for Chinese older adults: a development and feasibility study.BMC geriatrics · 2025Article
- Air pollution exposure associated with decline rates in skeletal muscle mass and grip strength and increase rate in body fat in elderly: a 5-year follow-up study.Environmental health and preventive medicine · 2025Article
- Analysis of potential categories and influencing factors of chronic disease comorbidity patterns among residents of Yantai City based on the health ecology model.Frontiers in public health · 2025Article
- Common Characteristics Between Frailty and Myotonic Dystrophy Type 1: A Narrative Review.Aging and disease · 2024Review
- Frailty and Survivability of Polish Caucasian Nonagenarians and Centenarians.Geriatrics (Basel, Switzerland) · 2024Article
- Predicting grip strength-related frailty in middle-aged and older Chinese adults using interpretable machine learning models: a prospective cohort study.Frontiers in public health · 2024Article
- [Differences between men and women in the prevalence of frailty and associated factors among older adults: evidence from ELSI-Brazil].Cadernos de saude publica · 2024Article
- Comparison of two handgrip dynamometers in older adults before elective surgery.Perioperative medicine (London, England) · 2023Article
- Nationwide handgrip strength values and factors associated with muscle weakness in older adults: findings from the Brazilian Longitudinal Study of Aging (ELSI-Brazil).BMC geriatrics · 2022Article
- Association between dietary inflammatory potential and the probable sarcopenia among community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough sarcopenia and frailty are important diseases in geriatrics, few studies have investigated the association between the two diseases. Thus, this study aimed to examine the relationship between two components of sarcopenia (muscle mass and muscle function) and frailty.
methodsIn total, 997 Korean older adults (456 men and 541 women) were included in this cross-sectional observational study. We used a polynomial linear regression analysis to obtain standardized sex, age, and height-adjusted appendicular skeletal muscle mass (zASM), as well as to standardized sex, age, and height-adjusted grip strength (zGS). We then performed a causal mediation analysis to confirm the relationship between zASM and frailty.
resultsIn both men and women, zGS mediated the relationship between zASM and frailty (average causal mediation effect in men: -0.096 {-0.159 to -0.050}; in women: -0.053 {-0.098 to -0.010}). For every one-point increase in zGS score, the relative risk of a one-point increase in frailty was reduced by 21% in men (e
conclusionsIn this study on Korean older adults, muscle mass did not have a direct effect on frailty but had an indirect effect through altered muscle function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.