ArticleStem cells translational medicine2020
Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Article in Stem cells translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 59 citations in OpenAlex.
- "Bioprinting of Hair: How Far We Proceeded and What Needs to be Done".Biotechnology and bioengineering · 2026Review
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine.ACS biomaterials science & engineering · 2026Article
- Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study.Stem cell research & therapy · 2025Article
- Synergizing biomaterials and cellular molecular pathways: a new frontier in hair follicle generation.Journal of translational medicine · 2025Review
- Recent progress in the identification and in vitro culture of skin organoids.Regenerative therapy · 2025Review
- 3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair follicle regeneration.Theranostics · 2025Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- Clinical and preclinical approach in AGA treatment: a review of current and new therapies in the regenerative field.Stem cell research & therapy · 2024Review
- Large-Scale Preparation of Hair Follicle Germs Using a Microfluidic Device.ACS biomaterials science & engineering · 2024Article
- A pig model exploring the postnatal hair follicle cycle.Frontiers in cell and developmental biology · 2024Article
- Molecular Mechanisms of Hair Follicle Development.TheScientificWorldJournal · 2024Review
- In vitro induction of hair follicle signatures using human dermal papilla cells encapsulated in fibrin microgels.Cell proliferation · 2024Article
- In vitro hair follicle growth model for drug testing.Scientific reports · 2023Article
- The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles.Cell and tissue research · 2023Review
- Injectable and biofunctionalized fibrin hydrogels co-embedded with stem cells induce hair follicle genesis.Regenerative biomaterials · 2023Article
- iPSC-based approach for human hair follicle regeneration.Frontiers in cell and developmental biology · 2023Review
- The Emergent Power of Human Cellular vs Mouse Models in Translational Hair Research.Stem cells translational medicine · 2022Article
- Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: A preliminary study conducted in mice.Bioengineering & translational medicine · 2022Article
- Tissue Engineering and Regeneration of the Human Hair Follicle in Androgenetic Alopecia: Literature Review.Life (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation into hair follicle replacement therapies has not occurred. Great expectation has been recently put on hair follicle bioengineering, which is based on the development of fully functional hair follicles with cycling activity from an expanded population of hair-inductive (trichogenic) cells. Most bioengineering approaches focus on in vitro reconstruction of folliculogenesis by manipulating key regulatory molecular/physical features of hair follicle growth/cycling in vivo. Despite their great potential, no cell-based product is clinically available for hair regeneration therapy to date. This is mainly due to demanding issues that still hinder the functionality of cultured human hair cells. The present review comprehensively compares emergent strategies using different cell sources and tissue engineering approaches, aiming to successfully achieve a clinical cure for hair loss. The hurdles of these strategies are discussed, as well as the future directions to overcome the obstacles and fulfill the promise of a "hairy" feat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.