Evidence map›Paper›PMID 31876232›Full record

ArticleChild neuropsychology : a journal on normal and abnormal development in childhood and adolescence2020

Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence.

Brian C Kavanaugh, Mary Kathryn Cancilliere, Alexa Fryc, Eric Tirrell, Jane Oliveira, Lindsay M Oberman, Bruce E Wexler, Linda L Carpenter, Anthony Spirito

Abstract read
In one paragraph

Article in Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Transdiagnostic Attentional Deficits Are Associated with Depressive and Externalizing Symptoms in Children and Adolescents with Neuropsychiatric Disorders.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
  6. Article
  7. Review
  8. Executive Functions and Public Health: A Narrative Review.Iranian journal of public health · 2023
    Review
  9. Article
  10. Longitudinal relations between impaired executive function and symptoms of psychiatric disorders in childhood.Journal of child psychology and psychiatry, and allied disciplines · 2022
    Article
  11. Article
  12. Article
  13. Observational
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Brian C KavanaughDepartment of Psychiatry & Human Behavior, Emma Pendleton Bradley Hospital , Providence, RI, USA.
Mary Kathryn CancilliereDepartment of Psychology, University of Rhode Island , South Kingstown, RI, USA.
Alexa FrycDepartment of Psychology, University of Rhode Island , South Kingstown, RI, USA.
Eric TirrellDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University , Providence, RI, USA.
Jane OliveiraDepartment of Psychiatry & Human Behavior, Emma Pendleton Bradley Hospital , Providence, RI, USA.
Lindsay M ObermanCenter for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine , Rockville, MD, USA.
Bruce E WexlerDepartment of Psychiatry, Yale University School of Medicine , New Haven, CT, USA.
Linda L CarpenterDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University , Providence, RI, USA.
Anthony SpiritoDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University , Providence, RI, USA.

Funding

Intramural NIH HHS Z99 MH999999
6 · The paper itself

Abstract

introductionDespite preliminary research, there remain inconsistent findings with regard to the role of executive functioning (EF) deficits in childhood anxiety and depression. This report examined the association of The National Institute of Health (NIH) Toolbox to clinical neuropsychological measures and to childhood, anxiety/depressive symptomatology. Methods: One-hundred eight children and adolescents completed the three EF measures from the NIH Toolbox (List Sorting Working Memory Test [LSWMT], Dimensional Change Card Sorting Test [DCCST], and Flanker Test of Attention and Inhibition [Flanker]) in an outpatient neuropsychology program. These tests were compared to established measures of EF in terms of linear correlations and detection of impairment. Heaton's Global Deficit Score (GDS) was utilized to calculate impairment. The Toolbox-EF measures were paired with parent-reported EF symptoms (Behavior Rating Inventory of Executive Function [BRIEF2]) to identify the role of EF in childhood anxiety/depressive symptomatology.

resultsToolbox-EF measures displayed medium sized correlations with their clinically comparable counterparts, and generally did not differ in their detection of impairment. Toolbox-GDS was associated with depression diagnosis and clinically significant child-reported anxiety and depressive symptoms. Together, Toolbox/BRIEF2 accounted for 26.8-30.9% of elevated depressive symptom variance, but only 13.2-14% of elevated anxiety symptom variance. Further, EF impairment was associated with depression across self report, parent report, and clinical diagnosis. DISCUSSION: The NIH Toolbox-EF measures display comparable psychometric properties to clinically available EF measures in a pediatric (primarily psychiatric) neuropsychology setting. The Toolbox appears to display an appropriate ability to detect EF deficits secondary to self-reported depression in childhood.

Indexed as

AdolescentAnxietyChildChild, PreschoolDepressionExecutive FunctionFemaleHumansMaleNational Institute of Mental Health (U.S.)Neuropsychological TestsUnited StatesanxietychildhooddepressionExecutive functioningNIH Toolbox

Identifiers

PMID31876232
PMCPMC10629577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.